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Metabolite Name
Meclocycline
(1)
Lysopa 18:0
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L-Hydroxylysine
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5,6-Dihydroxyindole-2-Carboxylic Acid
(1)
(+)-alpha-Lipoic acid
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L-Glutamic acid monosodium salt
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Lab affiliation
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA Purdue Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA Purdue Institute for Cancer Research, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA
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Max Delbrück Center for Molecular Medicine in the Helmholtz association (MDC) Robert-Rössle-Straße 10 13125 Berlin
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National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
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Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research and Jewish General Hospital, and McGill University, Montréal, Québec, Canada Gerald Bronfman Department of Oncology, McGill University, Montréal, Québec, Canada
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Tags
xref:PubMed:38918616
(3)
xref:PubMed:33443202
(2)
xref:PubMed:26147685
(2)
xref:PubMed:35383235
(1)
xref:PubMed:34255842
(1)
xref:PubMed:29042487
(1)
xref:PubMed:19735652
(1)
xref:PubMed:28723565
(1)
xref:PubMed:36629912
(1)
xref:PubMed:25403230
(1)
xref:PubMed:41397877
(1)
xref:PubMed:32132651
(1)
xref:PubMed:36279426
(1)
xref:PubMed:40037376
(1)
xref:PubMed:37709985
(1)
xref:PubMed:31253755
(1)
xref:PubMed:30459229
(1)
xref:PubMed:39357785
(1)
Keyword
Pembrolizumab
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Irinotecan
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Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers
Global and phosphoproteomic analysis to identify and characterize oncogenic pathways differentially regulated by the MNK/p70S6Ki, HSND80
ORGANISM(S):
Homo sapiens (Human)
2025-03-27
|
PXD057373
|
Pride
Anticancer
Kinase inhibitor
Tnbc
Small molecules
Mnki
Nsclc
P70s6ki
Cite
MNK Proteins as Therapeutic Targets in Leukemia.
Not available
S-EPMC10128080
|
biostudies-literature
Cite
Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia.
Not available
S-EPMC4987129
|
biostudies-literature
Cite
MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells.
Not available
S-EPMC3401333
|
biostudies-literature
Cite
Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening.
Not available
S-EPMC6800066
|
biostudies-literature
Cite
Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma.
Not available
S-EPMC6548590
|
biostudies-literature
Cite
Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses.
Not available
S-EPMC2981388
|
biostudies-literature
Cite
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
Not available
S-EPMC5321627
|
biostudies-literature
Cite
MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.
Not available
S-EPMC5082426
|
biostudies-literature
Cite
The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.
Not available
S-EPMC4436828
|
biostudies-literature
Cite
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