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ProteomicsMorpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers
Global and phosphoproteomic analysis to identify and characterize oncogenic pathways differentially regulated by the MNK/p70S6Ki, HSND80
ORGANISM(S): Homo sapiens (Human) 
2025-03-27 | PXD057373 | Pride
Anticancer Kinase inhibitor Tnbc Small molecules Mnki Nsclc P70s6ki 
UnknownPharmacologic Inhibition of Macrophage Triglyceride Biosynthesis Pathways Does Not Improve Mycobacterium tuberculosis Control in Infected Mice.
Not available
S-EPMC12128068 | biostudies-literature
ProteomicsAnalysis of insulin-regulated phosphorylation of AFF4 with Akti or S6ki and S6K invitro kinase
Aff4 was recently identified as an insulin-regulated phosphoprotein. To investigate upstream kinases, we analysed immunoprecipitated Aff4 treated with our without insulin and treated with either an Akti or a P70S6Ki. These results showed that AFF4 is dependent on P70S6K and therefore an in vitro kin...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-16 | PXD054247 | Pride
Akt P70s6k Phosphorylation Aff4 
UnknownAMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.
Not available
S-EPMC4284621 | biostudies-literature
UnknownRapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
Not available
S-EPMC3720125 | biostudies-literature
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