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MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
MetabolomicsNormalization techniques for PARAFAC modeling of urine metabolomics data
One of the body fluids often used in metabolomics studies is urine. The peak intensities of metabolites in urine are affected by the urine history of an individual resulting in dilution differences. This requires therefore normalization of the data to correct for such differences. Two normalization ...
2017-05-11 | MTBLS290 | MetaboLights
MetabolomicsMultiomics Longitudinal Modeling of Preeclamptic Pregnancies (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001890 | MetabolomicsWorkbench
MetabolomicsMultiomics Longitudinal Modeling of Preeclamptic Pregnancies (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001889 | MetabolomicsWorkbench
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
MetabolomicsA novel strategy for mining and identification of acylcarnitines using data-independent-acquisition (DIA) based retention time prediction modeling and pseudo-characteristic fragmentation ions matching
It is a challenging work to screen, identify, and quantify acylcarnitines in complex biological samples. A method, based on the retention time (RT) prediction and data-independent acquisition strategies, was proposed for the large-scale identification of acylcarnitines using liquid chromatography co...
2021-10-06 | MTBLS1932 | MetaboLights
MetabolomicsElucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale modeling
Not available
ORGANISM(S): Clostridioides difficile 
ST002433 | MetabolomicsWorkbench
MetabolomicsTFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001246 | MetabolomicsWorkbench
MetabolomicsMulti-omic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells
Not available
ORGANISM(S): Homo sapiens 
ST002052 | MetabolomicsWorkbench
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