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TranscriptomicsTranscriptional profiling of primary human alveolar macrophages challenged with Streptococcus pneumoniae from patients with chronic obstructive pulmonary disease compared to healthy donors
Transcriptional profiling of primary human alveolar macrophages (AMs) comparing control untreated AMs with AMs exposed with Serotype 14 Streptococcus pneumoniae (NCTC11902) strain (MOI 10) for 4 hours) Two-condition experiment, control AMs vs. infected AMs. Biological replicates: 3 control replicat...
ORGANISM(S): Homo sapiens 
2018-02-26 | E-MTAB-6491 | biostudies-arrayexpress
GenomicsAmplicon Sequencing of gRNAs from Brunello CRISPR mutagenized A549 and U87-MG cells after live/dead selection with EV-D68 IL
With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM)). In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outb...
ORGANISM(S): Homo sapiens 
2025-02-25 | E-MTAB-14765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human alveolar macrophages infected by B. anthracis spores
Bacillus anthracis is a gram-positive, aerobic, spore-forming, rod-shaped bacterium which has recently been used as an agent of bioterrorism. Because there is a significant delay between the initial contact of the spore with the host and clinical evidence of disease, there appears to be temporary co...
ORGANISM(S): Homo sapiens 
2009-10-16 | E-GEOD-14390 | biostudies-arrayexpress
TranscriptomicsExpression data from WEEV infected BE(2)-C/m cells
Analysis of transcription response of differentiated human BE(2)-C/m neuronal cells to infection with WEEV at 12 h and 24 h after infection. Two independent sets of BE(2)-C/m cells uninfected or infected with WEEV at an MOI=10 and harvested at 12 h or 24 h after infection. Total RNA was harvested a...
ORGANISM(S): Homo sapiens 
2013-11-23 | E-GEOD-52659 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Drosophila cells to FHV infection (infection experiment)
Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to infection with Flock House virus (FHV). Experiment Overall Des...
ORGANISM(S): Drosophila melanogaster 
2009-04-11 | E-GEOD-15466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BE(2)-C neuronal responses to WEEV infection
Human neuronal differentiation alters responsiveness to innate immune stimuli and virus infections. We used microarrays to examine the transcriptional responses of the human BE(2)-C neuroblastoma cell line to infection with western equine encephalitis virus (WEEV). Experiment Overall Design: Culture...
ORGANISM(S): Homo sapiens 
2009-07-12 | E-GEOD-16451 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from subjects infected with H.drcreyi reveals host susceptibility to H. ducreyi infection is associated with unique transcript profiles in tissue and dendritic cells
Comparison of gene expression from subjects who resolved or formed pustules to H.ducreyi. In human inoculation experiments, the cutaneous immune response to Haemophilus ducreyi consists of serum, PMN, macrophages, T cells and myeloid DC. In reinfection experiments, some subjects form pustules twice...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5547 | biostudies-arrayexpress
TranscriptomicsPrimary human blood-derived macrophages (BDMs): control vs. infected
Transcriptional profiling of primary human blood-derived macrophages (BDMs) comparing control untreated BDMs with BDMs exposed with Streptococcus pneumoniae strain D39 (MOI 0.1 and 0.5) for 16 hours) Two-condition experiment, control BDMs vs. infected BDMs. Biological replicates: 3 control replicate...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-77561 | biostudies-arrayexpress
UnknownImproved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small β-Globin Locus Control Region Elements.
Not available
S-EPMC6953778 | biostudies-literature
TranscriptomicsSequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation
The influenza polymerase cleaves host RNAs ~10–13 nucleotides downstream of their 5′ ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5′ ends of A/WSN/33 (H1N1) influenza mRNAs. T...
ORGANISM(S): Influenza A virus (A/WSN/1933(H1N1)) 
2015-04-23 | E-GEOD-65101 | biostudies-arrayexpress
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