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ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
ProteomicsThe yeast AIF homolog Nde1 integrates metabolic and proteostatic signals on the mitochondrial surface and executes cell death
Little is known about the proteolytic turnover of mitochondrial proteins under static growth conditions. Combining dynamic isotope labeling and mass spectrometry in yeast cells, we found an exceptionally high turnover for the NADH dehydrogenase Nde1. This homolog of the mammalian apoptosis inducing ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-06 | PXD012531 | Pride
Mitochondria Protein turnover Nde1 Yeast Apoptosis 
UnknownRisk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.
Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational coho...
S-EPMC10719096 | biostudies-literature
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