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MetabolomicsMetabolomics-based investigation on the molecular responses of Chaetoceros curvisetus under phosphorus limitation
Metabolomics was used in the present study to explore the molecular responses of Chaetoceros curvisetus to medium and low phosphorus stress.
2026-07-30 | MTBLS15209 | MetaboLights
TranscriptomicsDeconvolving the recognition of DNA shape from sequence
Binding of transcription factors to DNA is mediated by the recognition of the chemical signatures of the DNA bases and the three-dimensional shape of the DNA molecule. The direct contribution of DNA shape to DNA-binding specificity has been difficult to assess, as DNA shape is a consequence of its ...
ORGANISM(S): Drosophila melanogaster 
2015-01-21 | E-GEOD-65073 | biostudies-arrayexpress
TranscriptomicsU2AF1 mutations alter splice site recognition in hematological malignancies
Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 altered its normal role in RNA splicing. W...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-58871 | biostudies-arrayexpress
TranscriptomicsRNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation
Successful establishment and maintenance of pregnancy can be attained only through optimum conceptus-maternal cross talk. Despite significant progress in our understanding of the temporal changes in the transcriptome of the uterine endometrium, we have only a rudimentary knowledge of the genes and p...
ORGANISM(S): Bos taurus 
2014-04-04 | E-GEOD-56513 | biostudies-arrayexpress
TranscriptomicsEffect of Drosophila immune proteins on gene expression in E. coli
Interaction between the host and invading pathogen determines the fate of both organisms during the infectious state. The host is equipped with a battery of immune reactions, while the pathogen displays a variety of mechanisms to compromise host immunity. Although bacteria alter their pattern of g...
ORGANISM(S): Escherichia coli 
2015-01-13 | E-GEOD-61604 | biostudies-arrayexpress
GenomicsMolecular determinants of Hsp90 recognition of Src kinase revealed by deep mutational scanning
Molecular determinants of Hsp90 recognition of Src kinase revealed by deep mutational scanning
PRJNA902714 | ENA
GenomicsMassively parallel characterization of RNA G-quadruplex stability and molecular recognition
Massively parallel characterization of RNA G-quadruplex stability and molecular recognition
PRJNA1258079 | ENA
TranscriptomicsFunctional signature for the recognition of specific target mRNAs by human staufen1 protein
Cellular mRNAs are permanently associated to proteins in the form of ribonucleoprotein particles. In addition to the hnRNP and SR protein families, the double-stranded RNA-binding (DRB) proteins play important roles in mRNA synthesis, modification, activity and decay (Dreyfuss et al, 2002; Stutz & I...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-47226 | biostudies-arrayexpress
ProteomicsMolecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
Otu2-driven deubiquitylation of ribosomal protein eS7 impacts translational efficiency. Here, authors provide the molecular basis for recognition of monoubiquitinated eS7 on 40S and give mechanistic insights into Otu2’s role in translation reset. In this context quantitative mass spectrometry analys...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-13 | PXD041573 | Pride
Pulldown Translation Ubiquitination Otu2 Ubp3 
ProteomicsPhosphoproteome analysis in Arabidopsis thaliana when exposed to immunogenic molecular patterns
In plants, recognition of immunogenic molecular patterns, such as bacterial flagellin (flg22 epitope), leads to an enhanced state of immunity, designated pattern-triggered immunity (PTI). Following cognate ligand perception, pattern recognition receptors initiate sequential phosphorylation events to...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-09-18 | PXD015730 | JPOST Repository
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