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ProteomicsThe intrinsically disordered regions of organellophagy receptors control organelle fragmentation, ER-phagy and mitophagy flux
Organelle fragmentation is crucial for the onset of autophagic programs that control lysosomal clearance of portions of organelles to be removed from cells. It is driven by membrane-bound organello-phagy receptors that display cytoplasmic intrinsically disordered modules (IDRs) containing short LC3-...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD060519 | Pride
Fragmentation Intrinsically disordered regions Er-phagy Mitochondria Endoplasmic reticulum 
ProteomicsSec62 regulates ER-phagy during recovery from ER stress
Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzymes to reduce the burden of misfolded proteins. Upon resolution of ER stress, excess ER material is removed by ill-defined, selec...
ORGANISM(S): Homo sapiens (Human) 
2016-10-11 | PXD003961 | Pride
Autophagy Erad Endoplasmic reticulum Er stress Label-free quantitation 
ProteomicsEndogenous interactors of the natural trapping mutant TMX5/TXNDC15
The endoplasmic reticulum (ER) is the organelle of nucleated cells that produces lipids, sugars and proteins. More than 20 ER-resident members of the Protein Disulfide Isomerase (PDI) family regulate formation, isomerization and disassembly of covalent bonds in newly synthesized polypeptides. The PD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD054716 | Pride
Endoplasmic reticulum  erp44  mixed disulfides  pdi family  tmx5/txnd15 
ProteomicsChemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
The stress sensors ATF6, IRE1 and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigate...
ORGANISM(S): Homo sapiens (Human) 
2018-02-16 | PXD008529 | Pride
Proteomics Endoplasmic reticulum stress (er stress) Endoplasmic reticulum (er) Transcriptomics Proteostasis Unfolded protein response (upr) 
ProteomicsClients of membrane-bound PDI family members
The client-specificity of TMX3, TMX4 and TMX5 in cellula, was assessed by expressing mutant forms of the enzymes, where the last cysteine residue of the TMX’s CXXC catalytic sites has been mutated to alanine, which stabilizes the mixed disulfide that oxidoreductases establish with clients. Clients r...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD041156 | Pride
Trapping mutants Endoplasmic reticulum Oxidoreductases Mixed disulfides 
UnknownThe efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta-analysis.
Not available
S-EPMC11872969 | biostudies-literature
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