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TranscriptomicsTranscription profiling of activated mixed glial (microglia) and monocyte-derived macrophages
Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, m...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-1910 | biostudies-arrayexpress
TranscriptomicsRNAseq of primary human monocyte derived macrophages (MDM) and differentiated THP-1 macrophages exposed to graphene-related (nano)materials (GRMs)
Occupational and consumer exposure to GRMs will increase but their impact on human health is still largely unknown. We sought to perform a transcriptome comparison of the bioresponses of MDM and THP-1 macrophages exposed to 5 or 20 µg/ml graphene oxide (GO) or graphene nanoplatelets (GNP) for 6 and ...
ORGANISM(S): Homo sapiens 
2023-02-01 | E-MTAB-10099 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived macrophages reveals induction of dendritic cell-like phenotype in macrophages during foam cell formation
Foam cell formation from monocyte-derived macrophages is a hallmark of atheroscle-rotic lesions. Aspects of this process can be recapitulated in vitro by exposing MCSF-induced or platelet factor4 (CXCL4)-induced macrophages to oxidized (ox) or minimally modified (mm) low density lipoprotein (LDL). W...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7138 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected with HIV-1 or uninfected and stimulated with E. coli lipopolysaccharide
Whole genome expression profiling of HIV-1 infected and uninfected monocyte-derived macrophages
ORGANISM(S): Homo sapiens 
2009-01-01 | E-MEXP-1904 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
TranscriptomicsMonocyte-derived macrophages stimulated with the TLR8 agonist 3M-002 at 10 microM show a prominent activation of TLR-dependent genes as assessed b "Human Toll-like Receptor PCR array pathway" over time
We were interested in the effects of TLR8 triggering of human monocyte-derived macrophages. We observed a striking upregulation of those genes. This work was done in the context of examining the effects of TLR8 triggering for the activation of HIV. We generated monocyte-derived macrophages (MDM) by...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26470 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of pro-inflammatory phenotype of recently isolated human alveolar macrophages
Human alveolar macrophages and monocyte derived macrophages were compared using genome-wide transcriptional profiling.
ORGANISM(S): Homo sapiens 
2012-09-19 | E-TABM-1206 | biostudies-arrayexpress
TranscriptomicsEarly response of human monocyte-derived macrophages (MDM) to HIV-1
Human MDM were exposed to VSVG-pseudotyped HIV-1 NL-AD8 for 8h, 24h, and with HIV-1 + AZT for 24h MDM from 3 healthy blood donors were differentiated for 7 days, exposed or not to HIV-1 +/- AZT for 8h and 24h before being lysed. RNA was extracted, reverse-transcribed, hybridized on 2.1 ST microarray...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-81327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected with HIV-1 or stimulated with interferon-beta, interferon-gamma or lipopolysaccharide
Transcriptional profiling of HIV-1 infected and that of IFNbeta, IFNgamma or LPS stimulated human monocyte derived macrophages.
ORGANISM(S): Homo sapiens 
2009-09-01 | E-MEXP-2032 | biostudies-arrayexpress
TranscriptomicsA single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution (Bulk RNA-seq of capsular fibroblasts co-cultured with MDMs)
Bulk transcriptomic data of shoulder capsule fibroblasts isolated from frozen shoulder co-cultured with Dexamethasone (DEX) or LPS treated monocyte-derived macrophages (MDM), which were isolated from blood cones and stimulated with M-CSF, for 72 hours. The stimulated MDMs have been characterised as ...
ORGANISM(S): Homo sapiens 
2023-10-02 | E-MTAB-12312 | biostudies-arrayexpress
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