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UnknownCovalent Degrader of the Oncogenic Transcription Factor β-Catenin.
Not available
S-EPMC12102902 | biostudies-literature
UnknownCovalent Degrader of the Oncogenic Transcription Factor β-Catenin.
Not available
S-EPMC10635039 | biostudies-literature
UnknownDegradation by Design: New Cyclin K Degraders from Old CDK Inhibitors.
Not available
S-EPMC10804372 | biostudies-literature
UnknownDiscovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
Not available
S-EPMC11800961 | biostudies-literature
UnknownRational Design of CDK12/13 and BRD4 Molecular Glue Degraders.
Not available
S-EPMC12831537 | biostudies-literature
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065445 | Pride
Smarca2/4 E3 ligases  Protein degrader 
ProteomicsSelectivity profiling of inhibitor treated human cells via full proteome profiling
Three selective hit compounds from an arrayed kinome abundance screen (98 kinases vs 1570 kinase inhibitors) were subjected to full proteome profiling by TMTpro 18-plex to assess their degradation selectivity in K562 cells. Src inhibitor 3 showed the most significant downregulation of the target kin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD053130 | Pride
K562 Kinase inhibitors Monovalent degrader Tmt 
UnknownHeterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins.
Not available
S-EPMC10108347 | biostudies-literature
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065523 | Pride
E3 ligases  Smarca2/4 Protein degrader 
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