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ProteomicsArzanol Biomolecular Targets - Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase
The interactome of arzanol was investigated by MS-based chemical proteomics, a pioneering technology for small molecules target discovery. Brain glycogen phosphorylase (bGP), a key regulator of glucose metabolism so far refractory to small molecule modulation, was identified as the main high-affinit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011170 | Pride
Arzanol Chemical proteomics Brain glycogen phosphorylase 
ProteomicsDrug Affinity Responsive Target Stability unveils Filamins as biological targets for Artemetin, an anti-cancer flavonoid.
Artemetin is a valuable 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone found in many different medicinal plants with a very good oral bioavailability and drug-likeness values endowed with numerous bioactivities such as anti-inflammatory and anti-cancer ones. Here, a multi-disciplinary strategy has been d...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034776 | Pride
Anti-cancer. Bioactive natural compounds Drug affinity responsive target stability Cytoskeleton Proteomics 
ProteomicsA proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme
In the last few years, several efforts have been ended to identify original strategies against gli-oblastoma multiforme (GBM): this requires a more detailed investigation of the molecular mechanism of GBM so that novel targets can be identified for new possible therapeutic agents. Here, using a combi...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034933 | Pride
3-benzodiazepin-4-one Glycogen phosphorylase Proteomics 2 Target identification Glioblastoma multiforme 
ProteomicsA proteomic platform unveils PGK1 and 2 as potential target for Tatridin A
A multi-disciplinary strategy has been developed and applied for identifying Tatridin A target(s) to fully address its mechanism of action, based on drug affinity response target stability and targeted limited proteolysis. Both approaches point to the identification of PGK 1 and 2 (phospoglicerate k...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD034940 | Pride
Proteomics Natural compound Tatridin a Phosphoglicerate kinase 1 and 2 Target identification 
ProteomicsIdentification of Cannabidiol interactome in K562 cells
Cannabidiol (CBD) showed antiproliferative activity and induction of apoptosis in chronic myelogenous leukaemia cancer cells (K562 cells). A consolidated DARTS (Drug Affinity Response Target Stability) and t-LIP-MRM (targeted- Limited Proteolysis-Multiple Reaction Monitoring Mass spectrometry) platf...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD036650 | Pride
Cbd  k562 cells  top2a  darts  t-lip-mrm  chemoproteomics  mass spectrometry 
ProteomicsUnveiling Adaptive Molecular Mechanisms Through Comparative Proteomics of Potato Cell Responses to Abrupt and Gradual Water Deficits
Osmotic stress, such as drought and salinity, impairs plant growth, productivity, and food quality. Plants cope with these stresses by modulating biological processes and molecular mechanisms based on the stress intensity and duration. Understanding how plants respond and adapt at the molecular leve...
ORGANISM(S): Solanum tuberosum (Potato) 
2024-12-06 | PXD050665 | Pride
Proteomics Potato 
UnknownThe role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.
Not available
S-EPMC10513414 | biostudies-literature
UnknownHealth Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.
Not available
S-EPMC12492304 | biostudies-literature
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownFactors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial.
Not available
S-EPMC11187765 | biostudies-literature
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