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MetabolomicsEffects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in fla...
2020-06-03 | MTBLS952 | MetaboLights
MetabolomicsA thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice
Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we showed that Serinc2, a BD susceptibility gene encoding a L-serine transporter that regulates membrane lipid synthes...
2026-07-06 | MTBLS14954 | MetaboLights
MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
MetabolomicsThe nasal microbiome and metabolites are altered in depression patients
Depressive disorder is a heterogeneous neuropsychiatric disorder. It affects millions of people worldwide. The exact causes of depressive behavior remain unclear and are believed to implicate both genetic and environmental factors. In the past decade, there have been numerous studies on the dysbiosi...
2025-07-21 | MTBLS10742 | MetaboLights
TranscriptomicsTranscriptional profiling of monocytes of bipolar patients and controls
Bipolar disorder (BD) is a psychiatric disorder in which the core feature is pathological disturbance in mood ranging from extreme elation (mania) to severe depression. Study has shown an aberrant pro-inflammatory status of monocytes/macrophages in mood disorders. Therefore, this study aimed at stud...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-MEXP-1275 | biostudies-arrayexpress
TranscriptomicsHyper-excitability of Neurons generated from Patients with Bipolar Disorder
Bipolar Disorder (BD) is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression and, without treatment, 15% of patients commit suicide1. Hence, among all diseases, BD has been ranked by the WHO as a top disorder of morbidity and lost productivity2....
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-58933 | biostudies-arrayexpress
MetabolomicsBioinspired Nanozyme-Exoskeletonized Yeast-derived Polysaccharides for Treating Comorbid Anxiety and Depression in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for the deve...

2026-03-24 | MTBLS14127 | MetaboLights
TranscriptomicsAntenatal Blood DNA Methylation Profiles
DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and would not develop depression post partum. We recruited 54 pregnant women with a history of either Major Depression or Bipo...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-44132 | biostudies-arrayexpress
ProteomicsDysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients
A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-07 | MSV000086425 | MassIVE
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a s...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress
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