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TranscriptomicsNative functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
Spinobulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by expansion of a polyglutamine tract in the androgen receptor (AR). This mutation confers toxic function to AR through unknown mechanisms. Mutant AR toxicity requires binding of its hormone ligand, suggesting that pathogenesi...
ORGANISM(S): Drosophila melanogaster 
2010-09-23 | E-GEOD-23802 | biostudies-arrayexpress
TranscriptomicsExpression and Prognostic impact of LncRNAs in AML
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To ...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-63614 | biostudies-arrayexpress
UnknownRandomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.
Not available
S-EPMC3532391 | biostudies-literature
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) isolates
Salmonella enterica serovar Typhimurium (S. Typhimurium) definitive phage type 104 (DT104) has caused significant morbidity and mortality in humans and animals for almost three decades. We have completed the full DNA sequence of one DT104 strain, NCTC13348 and show that the main differences between ...
ORGANISM(S): Salmonella enterica 
2008-09-05 | E-MTAB-20 | biostudies-arrayexpress
TranscriptomicsHepatitis C virus functionally sequesters miR-122 [miR-122 KO vs Control CLIP]
Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infec...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64679 | biostudies-arrayexpress
MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (INTERVAL study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS834 | MetaboLights
UnknownA field evaluation of the Hardy TB MODS Kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis.
Not available
S-EPMC4167337 | biostudies-literature
TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
UnknownPrognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia.
Not available
S-EPMC3518729 | biostudies-literature
TranscriptomicsHepatitis C virus functionally sequesters miR-122 [HCV vs Mock CLIP]
Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infec...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64675 | biostudies-arrayexpress
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