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Friedreich’s ataxia (FA) is the most common monogenic mitochondrial disease. FA is caused by a depletion of the mitochondrial protein frataxin (FXN), an iron-sulfur (Fe-S) cluster biogenesis factor. To better understand the cellular consequences of FA, we performed quantitative proteome profiling of...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD045443 | Pride
Of the ~1100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive force (PMF) to execute signaling roles. To systematically identify genes that increase exclusively at the protein level upon PMF collapse, we performed a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD079746 | Pride
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-03 | MSV000079095 | MassIVE
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