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ProteomicsEffects of hypoxia on brain protein expression in a mouse model of Parkinson's disease
The purpose of this study was to evaluate whether chronic, continuous hypoxia (breathing 11% FIO2) would improve neurodegenerative disease in a mouse model of Parkinson's disease, which was modeled through intrastriatal injection of a-synuclein preformed fibrils (PFFs). We find that chronic, contin...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-14 | PXD063553 | Pride
Parkinson disease Brain Hypoxia Mouse Pff Substantia nigra 
TranscriptomicsMitochondrial and nuclear genomic response to loss of LRPPRC expression
Rapid advances in genotyping and sequencing technology have dramatically accelerated the discovery of genes underlying human disease. Elucidating the function of such genes and understanding their role in pathogenesis, however, remains challenging. Here, we introduce a genomic strategy to function...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20847 | biostudies-arrayexpress
UnknownComplementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.
Not available
S-EPMC4850741 | biostudies-literature
UnknownA Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.
Not available
S-EPMC7053407 | biostudies-literature
UnknownMICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Not available
S-EPMC3722067 | biostudies-literature
TranscriptomicsTranscription profiling of human skeletal muscle from males with type 2 diabetes to identify genes involved in oxidative phosphorylation
DNA microarrays can be used to discover gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coord...
ORGANISM(S): Homo sapiens 
2007-07-17 | E-CBIL-30 | biostudies-arrayexpress
UnknownA Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome
Not available
S-EPMC4644511 | biostudies-literature
TranscriptomicsGene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes
Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes. 4 samples were analyzed as two groups: shGFP (control) an...
ORGANISM(S): Mus musculus 
2012-10-12 | E-GEOD-40280 | biostudies-arrayexpress
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