Sort   by:  
 Page size 
ProteomicsEffect of systemic, low-dose LPS treatment on brain proteome of PFF-inoculated mice
Brain aggregates of α-synuclein (α-syn) characterizes a group of diseases defined as synucleinopathies. Recent studies implicate neuroinflammation as one of the central pathogenic mechanisms. However, how inflammation is linked to the α-syn pathology is still unknown. We wanted to address this by a ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-05 | PXD039193 | Pride
Alpha-synuclein Inflammation Lps Pff Lc-ms/ms 
GenomicsRole of Gpnmb in response to PFF-induced spreading alpha-synucleinopathy
Role of Gpnmb in response to PFF-induced spreading alpha-synucleinopathy
PRJNA687269 | ENA
GenomicsPFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [ATAC-seq]
PFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [ATAC-seq]
PRJNA1248479 | ENA
ProteomicsEndogenous alpha-synuclein is essential for the transfer of pathology by exosomes, following PFF inoculation in vivo.
Alpha-Synuclein (α-Syn) association with exosomes has been extensively studied both as a physiological process but also as a means of disease transmission under pathological conditions, via an elusive mechanism. Here, we utilized the preformed fibril (PFF) mouse model, as a source of brain-derived e...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-04 | PXD036301 | Pride
Pathology transmission Exosomes Alpha-synuclein (α-syn) Spreading Parkinson’s disease Pff 
GenomicsRNA-Seq in PBS- and mouse αSyn PFF-treated mouse primary cultured neurons
RNA-Seq in PBS- and mouse αSyn PFF-treated mouse primary cultured neurons
PRJNA1111384 | ENA
GenomicsPFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [ATAC-seq]
While there is significant progress in characterizing the pathogenesis of Parkinson's disease (PD), underlying cell biological events are less well-defined. Increasing evidence suggests that endolysosomal dysfunction is a critical driver of PD pathogenesis. In this study, we explored the impact of p...
ORGANISM(S): Mus musculus 
2026-05-13 | GSE294156 | GEO
GenomicsPFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [RNA-Seq]
PFF induce LRRK2-Mediated Rab5 Phosphorylation Triggering Lysosomal Dysfunction and Neuronal Senescence [RNA-Seq]
PRJNA1248436 | ENA
TranscriptomicsTranscription profiling of human primary foreskin fibroblasts following FCCP, oligomycin or AMP treatment
FCCP, Oligomycin and AMP lead to mitochondrial dysfunction. Here the influence of FCCP, Oligomycin and AMP on the transcriptome of PFF is examined.
ORGANISM(S): Homo sapiens 
2010-07-30 | E-MEXP-2285 | biostudies-arrayexpress
TranscriptomicsRole of Gpnmb in response to PFF-induced spreading alpha-synucleinopathy
Effect of Gpnmb knockout on development of differential expression in PFF-aSyn model was studied. The "sample_id" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0036142
ORGANISM(S): Mus musculus 
2021-06-18 | GSE163727 | GEO
UnknownIntegrated analysis of miRNA and mRNA expression profiles in p53-edited PFF cells.
Not available
S-EPMC7217372 | biostudies-literature
Sort   by:  
 Page size