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TranscriptomicsRNA profiling by deepSAGE sequencing in the cortex of a migraine mouse model after induction of cortical spreading depression
Familial Hemiplegic Migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the a1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (“FHM1 R192Q mice”) exhibi...
ORGANISM(S): Mus musculus 
2016-04-14 | E-GEOD-67933 | biostudies-arrayexpress
GenomicsLeo1 is a Global Regulator of Heterochromatin Cis-spreading
Domains of heterochromatin play important roles in the maintenance and regulation of eukaryotic genomes. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates the existence of robust mechanisms that limit heterochromatin spreading and thereby a...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-61688 | biostudies-arrayexpress
TranscriptomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [RNA-seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-49833 | biostudies-arrayexpress
ProteomicsProfiling of spreading- coupled protein tyrosine phosphorylation
Protein tyrosine phosphorylation is an important mechanism that regulates cytoskeleton reorganization and cell spreading of migratory cells. A number of cytoskeletal proteins are known to be tyrosine phosphorylated (pY) in different cellular processes. However, the profile of pY proteins during diff...
ORGANISM(S): Homo sapiens (Human) 
2016-09-28 | PXD004340 | Pride
Spreading Fibronectin Ecv304 
TranscriptomicsRoles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin
ChIP-chip analyses of ClrC components across the S. pombe genome. Keywords: ChIP-chip Chromatin immunoprecipitated DNA recovered with antibody against FLAG-tagged protein from wild-type asynchronous growing fission yeast cells and whole cell extracts DNA were amplified by random priming and respecti...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-25 | E-GEOD-10561 | biostudies-arrayexpress
ProteomicsEndogenous retroviruses promote prion-like spreading of proteopathic seeds
Prion-like spreading of protein misfolding is characteristic for neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigene...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-18 | PXD043201 | Pride
N2a Prion Retrovirus 
GenomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [MeDIP-Seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-44036 | biostudies-arrayexpress
TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
TranscriptomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [cDNA microarray]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-50016 | biostudies-arrayexpress
GenomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [DREAM]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-44038 | biostudies-arrayexpress
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