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TranscriptomicsTranscription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups
PURPOSE. The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). The recently proposed TC classification grouped MM patients into five classes on the basis of their cyclins D expression profiles and the presence of the main translocations involving the im...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2912 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human multiple myelome samples reveals up-regulation of translational machinery and distinct genetic subgroups characterize hyperdiploidy
Karyotypic instability, including numerical and structural chromosomal aberrations, represents a distinct feature of multiple myeloma (MM). 40-50% of patients displayed hyperdiploidy, defined by recurrent trisomies of non-random chromosomes. To characterize hyperdiploid (H) and nonhyperdiploid (NH) ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6401 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human plasma cells from patients with monoclonal gammopathy of undetermined significance, multiple myeloma or plasma-cell leukaemia
This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 7 monoclonal gammopathy of undetermined significance (MGUS), 39 newly diagnosed multiple myeloma (MM) and 6 plasma-cell leukaemia (PCL) patients. PCs were purified from bone marro...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bone marrow endothelial cells in patients with multiple myeloma
To determine a gene/molecular fingerprint of multiple myeloma (MM) endothelial cells (MMECs), also identifying some of the vascular mechanisms that govern the malignant progression from quiescent monoclonal gammopathy of undetermined significance (MGUS). A comparative gene expression profiling (GEP)...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-14230 | biostudies-arrayexpress
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia
This SuperSeries is composed of the following subset Series: GSE38611: Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression) GSE38613: Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38618 | biostudies-arrayexpress
TranscriptomicsMolecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia
Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic studies have shown that TP53 deletion in B-CLL is associated predominantly with 17p loss resulting ...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-GEOD-11038 | biostudies-arrayexpress
TranscriptomicsMolecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia, experiment A
Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic studies have shown that TP53 deletion in B-CLL is associated predominantly with 17p loss resulting ...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-GEOD-9992 | biostudies-arrayexpress
UnknownTranscriptomic Analysis in Multiple Myeloma and Primary Plasma Cell Leukemia with t(11;14) Reveals Different Expression Patterns with Biological Implications in Venetoclax Sensitivity.
Not available
S-EPMC8508148 | biostudies-literature
TranscriptomicsGenome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations
This SuperSeries is composed of the following subset Series: GSE39380: Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) GSE39381: Genome-wide analysis of primary plasma cell leukemia identifies recu...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-39383 | biostudies-arrayexpress
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