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TranscriptomicsRNA-seq-based analysis of the physiologic cold shock-induced changes in Moraxella catarrhalis gene expression
Background: Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid downshifts of environmental temperature when humans breathe cold air. The prevalence of pharyngeal colonization and respiratory tract infections caused by M. catarrhalis is greatest...
ORGANISM(S): Moraxella catarrhalis O35E 
2013-07-22 | E-GEOD-46256 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Moraxella catarrhalis RH4 during in vitro growth in brain heart infusion (BHI) medium
Transcriptome analysis of M. catarrhalis RH4 predicted coding sequences and clustered regularly interspaced short palindromic repeats (CRISPRs) regions. The results described in this study are further discussed in De Vries, S.P.W., van Hijum, S.A.F.T., Schueler, W., Riesbeck, K., Hays, J.P., Hermans...
ORGANISM(S): Moraxella catarrhalis RH4 
2010-05-07 | E-GEOD-21632 | biostudies-arrayexpress
TranscriptomicsM. catarrhalis Gene Expression in the Chinchilla Nasopharynx
M. catarrhalis strain O35E.rpsl was inoculated into the nasopharynx of healthy, male adult chinchillas. 24 hours later the nasopharyngeal tissues were extracted and homogenized. Total RNA was extracted from these tissue samples. Subsequently, M. catarrhalis genome directed primers were utilized t...
ORGANISM(S): Moraxella catarrhalis 
2012-04-03 | E-GEOD-13559 | biostudies-arrayexpress
ProteomicsSWATH-MS proteome of Moraxella catarrhalis under iron restricted conditions
Moraxella catarrhalis is a human-restricted bacterial pathogen that causes otitis media in children and exacerbations of chronic obstructive pulmonary disease in adults. Iron is a co-factor required for the function of proteins involved in respiration and DNA replication, and thus is essential to li...
ORGANISM(S): Moraxella catarrhalis 
2020-01-24 | PXD017206 | Pride
Moraxella catarrhalis Swath-ms Iron restriction 
TranscriptomicsIdentification of Gene Products Involved in the Oxidative Stress Response of Moraxella catarrhalis: Evaluation of OxyR dependent Genes
Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E and M. catarrhalis oxyR mutant response to 50 mM hydrogen peroxide. Wild-type cells and oxyR mutant cells were exposed to 50 mM hydrogen peroxide for 15 minutes. RNA was extracted and DNA microarray analysis performed. 4 biologic...
ORGANISM(S): Moraxella catarrhalis 
2010-12-07 | E-GEOD-24351 | biostudies-arrayexpress
TranscriptomicsIdentification of Gene Products Involved in the Oxidative Stress Response of Moraxella catarrhalis
Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E response to 50 mM hydrogen peroxide relative to a water-only control. Wild-type cells were exposed to either 50 mM hydrogen peroxide or a water-only control for 15 minutes. RNA was extracted and DNA microarray analysis performed...
ORGANISM(S): Moraxella catarrhalis 
2010-12-07 | E-GEOD-24331 | biostudies-arrayexpress
TranscriptomicsInteraction with Human Bronchial Epithelial Cells in vitro Affects Gene Expression in Moraxella catarrhalis
In this study, DNA microarray technology was used to measure global gene expression in M. catarrhalis cells that had attached to human bronchial epithelial cells in culture. M. catarrhalis ATCC 43617 was allowed to attach (MOI~30) to a monolayer of 16HBE14 human bronchial epithelial cells for 2 hr i...
ORGANISM(S): Moraxella catarrhalis 
2014-03-24 | E-GEOD-12990 | biostudies-arrayexpress
TranscriptomicsDeciphering the genetic basis of Moraxella catarrhalis complement resistance: Gene expression analysis of Moraxella catarrhalis BBH18 upon exposure to normal human serum.
The complement system is an important part of the innate defense against invading pathogens. The ability to resist complement-mediated killing is considered to be an important virulence trait for the human-restricted respiratory tract pathogen M. catarrhalis, as most disease-associated M. catarrhali...
ORGANISM(S): Moraxella catarrhalis BBH18 
2014-06-23 | E-GEOD-52552 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of Moraxella catarrhalis Grown in Pooled Human Sputum
Comparison of the gene expression profile of Moraxella catarrhalis grown in the presence of 20% pooled human sputum in chemically-defined medium relative to Moraxella catarrhalis grown in chemically-defined medium alone. Moraxella catarrhalis ATCC43617 was grown to mid-logarithmic phase either in th...
ORGANISM(S): Moraxella catarrhalis ATCC 43617 
2014-02-02 | E-GEOD-27059 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Zur Regulon of Moraxella catarrhalis
This series of microarrays explores the genes regulated by the Zur gene of Moraxella catarrhalis. The gene expression profile of O35E Wild-type cells was utilized as the baseline and compared with the gene expression profile of a non-polar mutant of the Zur gene constructed in the O35E background. ...
ORGANISM(S): Moraxella catarrhalis 
2014-03-23 | E-GEOD-28151 | biostudies-arrayexpress
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