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TranscriptomicsTranscriptional interaction network analyses in dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra in Parkinson's disease
We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary alo...
ORGANISM(S): Homo sapiens 
2015-01-11 | E-GEOD-43490 | biostudies-arrayexpress
TranscriptomicsIntragraft transcriptional profiling of renal transplant patients with tubular dysfunction after distinct immunosuppressive regimens
Intragraft transcriptional profiles were investigated in patients with tubular dysfunction to disclose subclinical mechanisms underlying graft deterioration. Moreover, we analyzed whether individualization of immunosuppression could modify this profile while improving renal function after 12 months ...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-48250 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Stem Cells from Human Umbilical Cord Blood
Uncovering the molecular mechanism of stem cell self-renewal is critical to broaden current therapeutic applications and to understand how its de-regulation may lead to pathological conditions. In this work, we report changes in gene expression and related cell processes during conditions of high in...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4609 | biostudies-arrayexpress
TranscriptomicsAIRE hypoexpression and transcriptome profiles correlate with thymic impairment in Down syndrome
Down syndrome (DS) patients frequently develop organ-specific autoimmune disorders, particularly endocrinopathies and coeliac disease, as well as an increased susceptibility to mucosal candidiasis. These clinical features resemble APECED (autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystroph...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-23910 | biostudies-arrayexpress
UnknownIntrauterine IPEX.
Not available
S-EPMC7714920 | biostudies-literature
UnknownAge-related transcriptional modules and TF-miRNA-mRNA interactions in neonatal and infant human thymus.
Not available
S-EPMC7159188 | biostudies-literature
ProteomicsTrypanosoma evansi secretome carries potential biomarkers for surra diagnosis
Trypanosoma evansi is a parasite of African origin that has evolutionary proximity to Trypanosoma brucei. This parasite, which causes the surra, has the broadest range of hosts, including wild and domestic mammals, and its geographic distribution is the widest among all trypanosomes. This disease ca...
ORGANISM(S): Trypanosoma evansi 
2023-03-04 | PXD031861 | Pride
Proteomic  bioinformatic  immunoinformatic  epitope 
UnknownPrevalence of Inflammatory Pathways Over Immuno-Tolerance in Peripheral Blood Mononuclear Cells of Recent-Onset Type 1 Diabetes.
Not available
S-EPMC8764313 | biostudies-literature
TranscriptomicsTranscriptional network analysis reveals that AT1 and AT2 Angiotensin II receptors are both involved in the regulation of genes essential for glioma progression
Gliomas are aggressive primary brain tumors, presenting surgery limitations due to their highly infiltrative potential. The expression of Angiotensin II (Ang II) receptors in human astrocytomas was previously associated with a poor prognosis. Accordingly, this study was undertaken to reveal the mole...
ORGANISM(S): Rattus norvegicus 
2014-12-20 | E-GEOD-47529 | biostudies-arrayexpress
UnknownDeclining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors.
Not available
S-EPMC7647114 | biostudies-literature
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