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ProteomicsIntegrated single cell functional-proteomic profiling of human skeletal muscle reveals a shift in cellular specificity in nemaline myopathy
Skeletal muscle is a complex syncytial arrangement of an array of cell types and, in the case of muscle specific cells (myofibers), sub-types. There exists extensive heterogeneity in skeletal muscle functional behaviour and molecular landscape, at the cell composition, myofiber sub-type and intra-my...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD061287 | Pride
Protein function-omics Nemaline myopathy Single muscle fiber 
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
ProteomicsHistamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans
Histamine receptor antagonists, commonly used to treat allergies, block histamine signalling and have been shown to impair acute and chronic adaptations to high-intensity and endurance-type exercise. Since it remains unclear whether this is a universal mechanism of muscle adaptation, this study inve...
ORGANISM(S): Homo sapiens (Human) 
2026-03-04 | PXD064353 | Pride
Fat mass Resistance training Food intake Muscle adaptations H1 antihistamines Histamine 
ProteomicsBeyond Myosin Heavy Chains in Human Skeletal Muscle Heterogeneity
Skeletal muscle is an inherently heterogenous tissue comprised primarily of myofibers, which are historically classified into three distinct fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X), delineated by the expression of myosin heavy chain isoforms (MYHs). However, w...
ORGANISM(S): Homo sapiens (Human) 
2025-02-27 | PXD046863 | Pride
Single muscle fiber  cell heterogeneity  myopathy  fiber type 
UnknownEffectiveness and safety of a microcrystalline tyrosine-adjuvanted Dermatophagoides pteronyssinus allergoid immunotherapy in adult patients with allergic asthma and rhinitis: A real-life prospective observational study.
Not available
S-EPMC9017636 | biostudies-literature
ProteomicsGLP-1 directed NMDA receptor antagonism for obesity treatment
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel critical to many processes in the brain. Genome-wide association studies (GWAS) suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity is important for body weight homeostasis1. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-26 | PXD045816 | Pride
Hypothalamus Glp-1 Obesity 
ProteomicsFibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta2‐Adrenergic Agonist
BackgroundSkeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individuals unable to engage in physical activity. Because beta2-adrenergic stimulation induces muscle growth wi...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD064789 | Pride
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