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MetabolomicsWeight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels.
Not available
ORGANISM(S): Homo sapiens 
ST000502 | MetabolomicsWorkbench
TranscriptomicsComparing the transcriptome profiling of ob/ob mice treated with the GLP-1 receptor agonist liraglutide, a clinically used GLP-1 receptor agonist, versus baseline controls
B6.Cg-Lep ob/ob mice females were surgically implanted in an age of 10-12 weeks with Alzet osmotic mini pumps (model 1002, 0,25l/h, Cupertino, CA, USA) in two groups of ten mice each to perform continuous subcutaneous infusions of Dulbecco's phosphate buffered saline (vehicle; n = 8) or GLP-1 (GLP-1...
ORGANISM(S): Mus musculus 
2017-09-03 | E-MTAB-6015 | biostudies-arrayexpress
TranscriptomicsCOUP-TFII Controls Mouse Postnatal Pancreatic β-Cell Mass through GLP-1 β-Catenin
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
2011-10-06 | E-GEOD-30526 | biostudies-arrayexpress
MetabolomicsMetabolomic and lipidomic profiles in response to exogenous insulin and GLP-1 infusions during prolonged fasting
Not available
ORGANISM(S): Mirounga angustirostris 
ST000107 | MetabolomicsWorkbench
MetabolomicsMetabolomic & lipidomic profiles in response to exogenous insulin & GLP-1 infusions during prolonged fasting (GCMS)
Not available
ORGANISM(S): Mirounga angustirostris 
ST000048 | MetabolomicsWorkbench
MetabolomicsActivation of ectopic olfactory receptor 544 induces GLP-1 secretion, alters gut microbiome, and improves intestinal permeability.
Not available
ORGANISM(S): Mus musculus 
ST001399 | MetabolomicsWorkbench
TranscriptomicsRNA-seq analysis comparing gene expression between mbk-1(-) and mbk-1(+) strains in daf-2(+), daf-2(-), glp-1(+) and glp-1(-) background
To identify genes whose expression in Caenorhabditis elegans is regulated by mbk-1 (ortholog of the human protein kinase DYRK1A implicated in Down syndrome) during adulthood, we performed whole transcriptome RNA-sequencing (RNA-seq) on mbk-1(+) and mbk-1(-) worms. To further account for the influenc...
ORGANISM(S): Caenorhabditis elegans 
2021-11-25 | E-MTAB-10898 | biostudies-arrayexpress
ProteomicsPhosphoproteomics evaluation of the effect of GLP-1 on the porcine pacemaker
GLP-1 induces an increase in heart rate, but its mechanism remains elusive. We used a phosphoproteomic approach to evaluate the effect of GLP-1 on the porcine sinus node. Tissue samples from the sinus node region and left ventricle were collected from eight animals following a 60-minute infusion wit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-10 | PXD042583 | Pride
Heart Phosphoproteomics Pig Pacemaker Glucagon-like peptide 1 Porcine Glp-1 Sinus node 
ProteomicsGLP-1 directed NMDA receptor antagonism for obesity treatment
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel critical to many processes in the brain. Genome-wide association studies (GWAS) suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity is important for body weight homeostasis1. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-26 | PXD045816 | Pride
Hypothalamus Glp-1 Obesity 
ProteomicsMetabolic regulation of feeding affinity behavior through GLP-1-like signaling
Metabolic regulation of feeding affinity behavior through GLP-1-like signaling
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2024-11-04 | MSV000096286 | MassIVE
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