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ProteomicsTargetSeeker-MS: A Bayesian Inference Approach for Drug Target Discovery using Protein Fractionation Coupled to Mass Spectrometry
Determining the affinity of a drug to its putative targets is critical to the understanding of its mechanism and to assess its clinical usefulness and viability. Energetics-based protein separation (EBPS) techniques, such as thermal shift assay, when coupled to mass spectrometry (MS) have shown grea...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-04-06 | PXD010799 | Pride
Bioinformatics / drug target discovery / mass spectrometry / proteomics / thermal shift assay 
ProteomicsFunction of the MYND domain and C-terminal region in regulating the subcellular localization and catalytic activity of the SMYD family lysine methyltransferase Set5
SMYD lysine methyltransferases target histones and non-histone proteins for methylation and are critical regulators of muscle developmental and implicated in neoplastic transformation. They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, as well as an ex...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-11 | PXD014756 | Pride
Methyltransferase Saccharomyces cerevisiae 
ProteomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
The mammalian BRG1-associated factors (BAF) complex is a multi-subunit chromatin remodeling complex that is an important component of the embryonic stem cell (ESC) transcriptional regulatory network. However, the role of individual subunits in BAF complex targeting and function needs to be elucidate...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010670 | Pride
Baf Chromatin remodeling 
ProteomicsEssential requirement for IER3IP1 in B cell development
In a forward genetic screen of mice with N-ethyl-N-nitrosourea (ENU)-induced mutations for aberrant immune function, we identified animals with low percentages of B220+ cells in the peripheral blood. The causative mutation was in Ier3ip1, encoding immediate early response 3 interacting protein 1 (IE...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-09 | MSV000091025 | MassIVE
GenomicsChIP-seq analysis of H3K9me3 levels across the genome for one copy of H3K9M mutant in pombe
We performed ChIP-seq analyses for WT, H3K9M mutant and clr4 mutant in Schizosaccharomyces pombe, and showed that H3K9me3 level was reduced to background levels across the entire genome, similar to clr4 mutant.
ORGANISM(S): Schizosaccharomyces pombe 
2016-10-03 | E-MTAB-4776 | biostudies-arrayexpress
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
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