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TranscriptomicsStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes
Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known alrea...
ORGANISM(S): Homo sapiens 
2015-09-19 | E-GEOD-69768 | biostudies-arrayexpress
UnknownTolerability of Eribulin and correlation between polymorphisms and neuropathy in an unselected population of female patients with metastatic breast cancer: results of the multicenter, single arm, phase IV PAINTER study.
Not available
S-EPMC9615373 | biostudies-literature
TranscriptomicsLeishmania major: Sir2rp3 overexpressor vs wild-type
Transcriptional profiling of Leishmania major parasites overexpressing LmSir2rp3 protein compared with wild-type cell line transfected with empty vector in normal growth conditions. Goal of this experiment was to evaluate the possible effect of LmSir2rp3 in the control of gene expression in this pro...
ORGANISM(S): Leishmania major 
2012-09-10 | E-GEOD-38731 | biostudies-arrayexpress
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patientsM-bM-^@M-^Y relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 12...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-35953 | biostudies-arrayexpress
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
TranscriptomicsGene Expression profiles of human pediatric medulloblastoma
Medulloblastoma (MB) is one of the most common malignant pediatric brain tumor. The aim of our study was to understand which mechanisms are involved in aberrant activation of Wnt pathway and its association with MB tumor development. We studied the expression profiles of 19 MBs tumors using a genome...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39182 | biostudies-arrayexpress
TranscriptomicsMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is expressed at high levels in myofibers of adult skeletal muscle, but its function is unknown. Here we show that knockdown of MRF4 in adult muscle causes hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthes...
ORGANISM(S): Rattus norvegicus 
2016-07-15 | E-GEOD-67069 | biostudies-arrayexpress
TranscriptomicsThe bone marrow microenvironment in patients with neuroblastoma: presence of IFN signature and significant down-regulation of CXCL12 expression
Neuroblastoma (NB) is the most common extra cranial solid tumor in infants. Although several risk factors including patient age, disease stage and genetic abnormalities, such as MYCN amplification and 11q deletion, have been shown to predict outcome, the mechanisms responsible for the heterogeneous ...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-25624 | biostudies-arrayexpress
UnknownThe effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study.
Not available
S-EPMC3191151 | biostudies-literature
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