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MetabolomicsPseudomonas syringae infectivity correlates to altered transcript and metabolite levels of Arabidopsis Mediator mutants

Rapid metabolic responses to pathogens are essential for plant survival and depend on numerous transcription factors. Mediator is the major transcriptional co-regulator for integration and transmission of signals from transcriptional regulators to RNA polymerase II. Using four Arabidopsis Mediato...

2024-02-19 | MTBLS8105 | MetaboLights
MetabolomicsFunctional metabolomics as a tool to analyze Mediator function and structure in plants
Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localiz...
2018-01-30 | MTBLS450 | MetaboLights
UnknownChallenging aspects of treatment strategies in heart failure with preserved ejection fraction: "Why did recent clinical trials fail?".
Not available
S-EPMC4577681 | biostudies-literature
OtherCell physiology of the biotechnological relevant bacterium Bacillus pumilus-an omics-based approach.
Data from ProteomeXchange, PXD ID: PXD000780. Experiment: O2_U1_gmr_sh_11_1, file: 100223_O2_U1_gmr_sh_11_1_4.mzml. Published as part of J Biotechnol. 2014 Dec 20;192 Pt A:204-14 . From the Abstract: {{i}} Members of the species Bacillus pumilus get more and more in focus of the biotechnological in...
ORGANISM(S): Crap, Bacillus_pumilus_safr_032 
GPM32310018327 | GPMDB
Resource Reanalysis 
ProteomicsA global Staphylococcus aureus proteome resource applied to the in vivo characterization of host- pathogen interactions
1. DDA dataset used for Staphylococcus aureus HG001 PeptideAtlas build (https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/buildDetails?atlas_build_id=435) 2. DIA and DDA dataset for the quantitative analyses of the publication (in the update section)
ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Nctc 8325 (ncbitaxon:93061) Homo Sapiens (ncbitaxon:9606) 
2018-06-21 | MSV000082483 | MassIVE
GenomicsChIP-seq-based analysis of differential K27me3 coverage in neuroblastoma cell lines treated with epigenetic drugs
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on H3K27me3 coverage was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in RNA expression and DNA methylation. The neuroblastoma cell lines Be(2)-C and IMR5-7...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-80445 | biostudies-arrayexpress
MetabolomicsDissolved organic carbon compounds in deep-sea hydrothermal vent fluids from the East Pacific Rise at 9°50′N

Deep-sea hydrothermal vents are unique ecosystems that may release chemically distinct dissolved organic matter to the deep ocean. Here, we describe the composition and concentrations of polar dissolved organic compounds observed in low and high temperature hydrothermal vent fluids at 9°50′N on t...

2017-05-23 | MTBLS428 | MetaboLights
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
ProteomicsChemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation
Modification of native cysteine is an important tool in protein research and relies on fast and chemoselective reactions under bioambient conditions. Nucleophilic cysteine can be functionalized with electrophiles, such as maleimides, that carry specific chemical groups, depending on the desired appl...
ORGANISM(S): Escherichia Coli 
2023-12-20 | PXD038723 | JPOST Repository
ProteomicsM.tuberculosis - Whole organism, absolute concentration (Schubertetal,cellhostmicrobe2014)
abundance based on absolute concentration, Interaction consistency score: 1.0, Coverage: 46
ORGANISM(S): 83332 
2014-00-00 | 2118471723 | PAXDB
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