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TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsGenome Haploidisation with Chromosome 7 Retention in Oncocytic Follicular Thyroid Carcinoma
Recurrent non-medullary thyroid carcinoma (NMTC) is a rare disease. We initially characterized 27 recurrent NMTC: 13 papillary thyroid cancers (PTC), 10 oncocytic follicular carcinomas (FTC-OV), and 4 non-oncocytic follicular carcinomas (FTC). A validation cohort composed of benign and malignant (bo...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-31828 | biostudies-arrayexpress
TranscriptomicsGenotyping of human chromosomal instability patterns discriminates rectal adenomas from carcinomas
Total mesorectal excision (TME) is the standard treatment for rectal cancer, while transanal endoscopic microsurgery (TEM) is a recently introduced surgical approach for the treatment of rectal adenomas. Incorrect preoperative staging before TEM is a problem. To identify genetic changes that migh...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-7946 | biostudies-arrayexpress
TranscriptomicsIntegrating chromosomal aberrations and gene expression profiles to dissect rectal cancer
Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that loss of 1q was related to lymph node metastasis. In order to find markers f...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12225 | biostudies-arrayexpress
TranscriptomicsHigh Resolution Copy Number Analysis of Paraffin Embedded Archival Tissue Using SNP BeadArrays
High density SNP microarrays provide insight into the genomic events that occur in diseases like cancer by their capability to measure both LOH and genomic copy numbers. Where currently available methods are restricted to the use of fresh frozen tissue, we now describe the design and validation of c...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5347 | biostudies-arrayexpress
TranscriptomicsBAC CGH array profiling using Phi29-amplified microdissected samples
Details of the experiment are available within the Nucleic Acid Research, 2004 manuscript "Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH", by Cardoso J. et al.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1841 | biostudies-arrayexpress
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