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GenomicsGenome-wide map of RNA polymerase II, NELF, and DSIF in HeLa cells
Most metazoan promoters have RNA polymerase II (Pol II) paused slightly downstream of the transcription start site by NELF and DSIF. This pausing keeps these promoters available for rapid induction by P-TEFb, whose activity causes NELF to dissociate and Pol II and DSIF to elongate on the gene. ChIP-...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-53008 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of stripe rust infected wheat leaves and isolated haustoria
The fungus Puccinia striiformis f.sp. tritici (PST) is the causal pathogen of stripe rust in wheat. New highly virulent PST races appeared at the beginning of this century and spread rapidly causing significant yield losses in wheat production worldwide. Race PST-08/21 was isolated in the UK in 2008...
ORGANISM(S): Puccinia striiformis f. sp. tritici 08/21 
2013-08-19 | E-GEOD-42496 | biostudies-arrayexpress
TranscriptomicsIdentification of Components Associated with Thermal Acclimation of Photosystem II in Synechocystis sp. PCC6803
Photosystem II (PSII) is the most thermally sensitive component of photosynthesis. Thermal acclimation of this complex activity is likely to be critically important to the ability of photosynthetic organisms to tolerate temperature changes in the environment. We have analysed gene expression using w...
ORGANISM(S): Synechocystis sp. PCC 6803 
2010-04-09 | E-GEOD-21133 | biostudies-arrayexpress
TranscriptomicsFunction of Periplasmic Hydrogenases in the Sulfate-Reducing Bacterium Desulfovibrio vulgaris Hildenborough
The sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough possesses four periplasmic hydrogenases to facilitate the oxidation of molecular hydrogen. These include an [Fe], a [NiFeSe] and two [NiFe] hydrogenases encoded by the hyd, hys, hyn1 and hyn2 genes, respectively. In order to underst...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2010-06-10 | E-GEOD-8137 | biostudies-arrayexpress
TranscriptomicsDevelopment and evaluation of a 60-mer oligonucleotide microarray for profiling of biodegradation and bacterial 16S rRNA genes in diverse contaminated ecosystems
We have developed a 60-mer oligonucleotide multibacterial microarray for detection and expression profiling of biodegradative genes and bacterial diversity (16S rRNA gene) in different habitats contaminated with varieties of hazardous chemicals. The genes selected were involved in biodegradation and...
ORGANISM(S): Bordetella sp. IITR-02 
2011-04-15 | E-GEOD-24353 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice
We report that 7 of 7 female Gnmt-/- mice developed hepatocellular carcinoma (HCC), the most common form of liver cancer, at the mean age of 16.1 months. In contrast, only one-third (2/6) of male Gnmt-/- mice had HCC, the remaining had either premature death or liver necrosis. Microarray analysis sh...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-9809 | biostudies-arrayexpress
TranscriptomicsIn vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-60388 | biostudies-arrayexpress
TranscriptomicsImpact of Velvet complex on transcriptome and penicillin G production in glucose-limited chemostat cultures of a beta-lactam high-producing Penicillium chrysogenum strain
The multi-component global regulator Velvet complex has been identified as a key regulator of secondary metabolite production in Aspergillus and Penicillium species. Previous work indicated a massive impact of PcvelA and PclaeA deletions, two key components of the Velvet complex, on penicillin produ...
ORGANISM(S): Penicillium chrysogenum 
2011-12-06 | E-GEOD-31633 | biostudies-arrayexpress
TranscriptomicsCandidate genes for alcohol preference in alcohol-preferring and non-preferring reciprocal congenic rats
The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in 5 brain regions of alcohol-naïve iP and P.NP rats. Background: Selectively bred P (alcohol preferring) and NP (alcohol non-preferring) rats differ greatly in alcohol prefere...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15415 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the Retina after Transcorneal Electrical Stimulation in Wildtype Brown Norway Rats
Purpose: To investigate the effect of transcorneal electrical stimulation (TES) on the retina of wildtype Brown Norway (BN) rats by gene expression profiling. Methods: TES was applied to BN adult wildtype rat retina in vivo for 1h (1ms biphasic pulses at 20Hz; current: 200 M-BM-5A). RNA was isolated...
ORGANISM(S): Rattus norvegicus 
2011-11-21 | E-GEOD-26174 | biostudies-arrayexpress
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