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ProteomicsPronucleotide probes reveal a diverging specificity for AMPylation vs. UMPylation of human and bacterial nucleotide transferases
AMPylation is a post-translational modification utilized by human and bacterial cells to modulate the activity and function of specific proteins. Major AMPylators such as human FICD and bacterial VopS have been studied extensively for their substrate and target scope in vitro. Recently, an AMP pronu...
ORGANISM(S): Homo sapiens (Human) 
2024-02-27 | PXD045925 | Pride
Infection Ampylation Vops Umpylation Pronucleotide 
ProteomicsTarget identification of usnic acid in bacterial and human cells
Usnic acid is a natural product with versatile biological activities against various organisms. We here utilize a chemical proteomic strategy to gain insights into its target scope in bacterial and human cells. First, we excluded DNA binding as a major reason for its antibacterial activity and secon...
ORGANISM(S): Homo sapiens (Human) Enterococcus faecalis (Streptococcus faecalis) 
2024-08-10 | PXD049013 | Pride
Abpp Usnic acid 
ProteomicsTailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly
Treatment of Mycobacterium tuberculosis infections is a challenging task due to a growing number of resistant clinical isolates as well as an almost empty drug development pipeline. To identify new antibiotic hits, we screened a focused library of 400 synthetic compounds derived from a recently disc...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2025-05-06 | PXD050993 | Pride
Tuberculosis Afbpp 
ProteomicsTarget Identification of Lagunamide A
Lagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsi...
ORGANISM(S): Homo sapiens (Human) 
2024-06-09 | PXD042129 | Pride
Natural product Tmt-10plex Lagunamide a Thermal proteome profiling Target id 
UnknownCommon genetic variants influence human subcortical brain structures.
Not available
S-EPMC4393366 | biostudies-literature
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