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UnknownSalmonella Facilitates Iron Acquisition through UMPylation of Ferric Uptake Regulator.
Not available
S-EPMC9239237 | biostudies-literature
ProteomicsPronucleotide probes reveal a diverging specificity for AMPylation vs. UMPylation of human and bacterial nucleotide transferases
AMPylation is a post-translational modification utilized by human and bacterial cells to modulate the activity and function of specific proteins. Major AMPylators such as human FICD and bacterial VopS have been studied extensively for their substrate and target scope in vitro. Recently, an AMP pronu...
ORGANISM(S): Homo sapiens (Human) 
2024-02-27 | PXD045925 | Pride
Infection Ampylation Vops Umpylation Pronucleotide 
UnknownPolypeptide encoded by the -1 PRF signal of SARS-CoV-2 controls multiple enzymatic activities of the viral NiRAN domain.
Not available
S-EPMC12628317 | biostudies-literature
TranscriptomicsAntisense Transcripts Impede Uridylation-induced Exonucleolytic Degradation to Generate Guide RNAs
Small non-coding RNA biogenesis typically involves cleavage of structured precursors by RNase III-like endonucleases. However, guide RNAs that direct U-insertion/deletion mRNA editing in mitochondria of trypanosomes maintain 5′ triphosphate characteristic of transcription start site and possess U-...
ORGANISM(S): Trypanosoma brucei 
2016-02-08 | E-GEOD-71292 | biostudies-arrayexpress
TranscriptomicsDifferentiated Truncation and Uridylation Patterns of miRNAs in Arabidopsis and Rice hen1 Mutants Suggest miRNAs May Re-program RISC
miRNA levels depend on both biogenesis and turnover. The methyltransferase HEN1 stabilizes plant miRNAs, animal piRNAs, and siRNAs in both kingdoms via 3' terminal methylation. Loss of HEN1 in plants results in non-templated oligo-uridylation and accelerated degradation of miRNAs. In hen1 mutants fr...
ORGANISM(S): Arabidopsis thaliana 
2013-07-22 | E-GEOD-35562 | biostudies-arrayexpress
UnknownCoronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.
Not available
S-EPMC8017715 | biostudies-literature
TranscriptomicsGlobal view of mRNA uridylation in Arabidopsis
To obtain a global view of mRNA uridylation in Arabidopsis, we generated TAIL-seq libraries from WT plants, urt1 and xrn4 single mutants, and urt1 xrn4 double mutant. The TAIL-seq protocol was recently developed to deep-sequence the 3' ends of RNAs (Chang et al., 2014). We generated TAIL-seq librari...
ORGANISM(S): Arabidopsis thaliana 
2016-03-11 | E-GEOD-72457 | biostudies-arrayexpress
TranscriptomicsC. elegans small RNAs
High throughput sequencing to derive function of cde-1 in endogenous RNAi in C. elegans Small RNAs were cloned from C. elegans adults, following removal of tri-phosphate groups from 5' end. Sequencing was performed using the Illumina 1G platform.
ORGANISM(S): Caenorhabditis elegans 
2009-10-06 | E-GEOD-17787 | biostudies-arrayexpress
TranscriptomicsSmall RNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precursor...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-35835 | biostudies-arrayexpress
TranscriptomicsmRNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precur...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40228 | biostudies-arrayexpress
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