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ProteomicsMclX modulates the process of mother cell lysis by SpoIIID in Bacillus thuringiensis
Cell differentiation is essential for the survival and adaptation of organisms. In Bacillus species, sporulation is a tightly coordinated program that culminates in mother cell lysis, a critical step for spore release. Despite its importance, the mechanisms modulating the process remain poorly under...
ORGANISM(S): Bacillus thuringiensis 
2026-07-15 | PXD070258 | Pride
Mother cell lysis initiation Bacillus thuringiensis Protein of unknown function mclx Hydrolase gene cwlc Transcriptional regulator spoiiid 
ProteomicsSPOROCYTELESS/NOZZLE interacts with MADS-DOMAIN transcription factors during the megaspore mother cell differentiation in the Arabidopsis ovule
This dataset contains proteomic data from co-immunoprecipitation and mass spectrometry (IP-MS) experiments performed to identify in planta interaction partners of the transcriptional regulator SPOROCYTELESS/NOZZLE (SPL) during Arabidopsis thaliana ovule development. SPL is an essential regulator of ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-11-18 | PXD070409 | Pride
ProteomicsInheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy - Pride 2
T cell immunity is impaired during ageing, particularly in memory responses needed for efficient vaccination. Autophagy and asymmetric cell division (ACD) are cell biological mechanisms key to memory formation, which undergo a decline upon ageing. However, despite the fundamental importance of these...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD053316 | Pride
Mitochondria Cd* t cells 
TranscriptomicsMicroarray of 3D cultured basal cells in the presence of Wnt3A
Adult stem cells have the ability to self-renew and to generate specialized cells. Self-renewal is dependent on extrinsic niche factors but few of those signals have been identified. We show that adult mammary glands contain a Wnt-responsive cell population that is enriched for stem cells. In cell c...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-55117 | biostudies-arrayexpress
TranscriptomicsEffect of aging on the meiotic cell cycle
Identify which stages of meiosis are impaired in replicative aging cells Transcriptional profile of aging yeast cells (young and old) incubated in sporulation-inducing conditions compared to new-born cells grown in vegetative conditions. Two conditions experiments. Young and Old cells incubated in ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-08 | E-GEOD-15570 | biostudies-arrayexpress
TranscriptomicsExpression data from chemically-induced skin squamous cell carcinomas
Cancer stem cells (CSCs) have been reported in various cancers including skin squamous cell carcinoma (SCC). The molecular mechanisms regulating tumour initiation and stemness are still poorly characterized. Here, we found that Sox2, a transcription factor expressed in various types of embryonic and...
ORGANISM(S): Mus musculus 
2014-06-08 | E-GEOD-55737 | biostudies-arrayexpress
TranscriptomicsPhysiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
We report a Jak2V617F knock-in mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we demonstrate that the hematopoietic stem cell (HSC) compartment has the unique capacity for disease initiation but does not have a selective ...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21842 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human mesenchymal stem cells to identify Argonaute1 bound mRNAs and to identify mRNAs expressed by the human embryo stem cell line H1 before and after differentiation along the neural lineage.
Gene expression profiles were generated with Illumina arrays for untreated human mesenchymal stem cells and also Argonaute1 bound mRNAs in the same cells. In addition gene expression profiles were generated for the human embryo cell line H1 before and after differentiation along the neural lineage....
ORGANISM(S): Homo sapiens 
2010-12-20 | E-TABM-1001 | biostudies-arrayexpress
TranscriptomicsExpression data from chemically-induced skin papillomas (benign tumours)
Cancer stem cells (CSCs) have been reported in various cancers including skin squamous cell carcinoma (SCC). The molecular mechanisms regulating tumour initiation and stemness are still poorly characterized. Here, we found that Sox2, a transcription factor expressed in various types of embryonic and...
ORGANISM(S): Mus musculus 
2014-06-08 | E-GEOD-55738 | biostudies-arrayexpress
TranscriptomicsNucleosome loss leads to global transcriptional upregulation and genomic instability during yeast replicative aging
All eukaryotic cells divide a finite number of times, termed replicative aging, but the reason for this is not clear. Consistent with the decreased total histone protein levels in aged Saccharomyces cerevisiae, which is a cause of aging (1), we find that nucleosome occupancy decreases 50% across the...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-26 | E-GEOD-47023 | biostudies-arrayexpress
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