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GenomicsHoxc9 ChIP-seq in differentiating motor neurons
The expression of v5-tagged Hoxc9 is induced and ChIP-seq is used to profile genome-wide occupancy in differentiating motor neurons The differentiation of ventral motor neurons is induced by treating embryonic stem cell cultures with retinoic acid and hedgehog signaling. Here, ChIP-seq is used to pr...
ORGANISM(S): Mus musculus 
2010-09-08 | E-GEOD-21812 | biostudies-arrayexpress
ProteomicsMuscle stem cell maintenance and regeneration of skeletal muscle require functional motor innervation
Background: Skeletal muscle crucially depends on motor innervation, and, when damaged, on the resident muscle stem cells (MuSCs). However, the role and function of MuSCs in the context of denervation remains poorly understood. Methods: Alterations of MuSCs and their myofiber niche after denervation...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-27 | PXD036993 | Pride
Muscle stem cell Motor innervation Skeletal muscle Denervation Myofibers 
UnknownThe Geometry of Limb Motor Innervation is Controlled by the Dorsal-Ventral Compartment Boundary in the Chick Limbless Mutant.
Not available
S-EPMC9922539 | biostudies-literature
GenomicsEtv1 controls the establishment of non-overlapping motor innervation of neighboring facial muscles during development
Etv1 controls the establishment of non-overlapping motor innervation of neighboring facial muscles during development
PRJNA556454 | ENA
TranscriptomicsTranscription profiling of different types of adult mouse motoneuron columnar cells to compare their molecular characteristics
Studies in the developing spinal cord suggest that different motoneuron (MN) cell types express very different genetic programs, but the degree to which adult programs differ is unknown. To compare genetic programs between adult MN columnar cell types, we used laser capture microdissection (LCM) and...
ORGANISM(S): Mus musculus 
2007-08-09 | E-GEOD-2595 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing to neuromuscular deficits. We investigated differentially expressed genes (DEG) in muscle following peroneal nerve crush to model of motor un...
ORGANISM(S): Mus musculus 
2022-01-10 | E-MTAB-10601 | biostudies-arrayexpress
UnknownDOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice.
Not available
S-EPMC7452162 | biostudies-literature
Unknownβ-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice.
Not available
S-EPMC3358465 | biostudies-literature
GenomicsSympathetic innervation regulates metabolic plasticity of skeletal muscle
Sympathetic innervation regulates metabolic plasticity of skeletal muscle
PRJNA1207043 | ENA
UnknownThe sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.
Not available
S-EPMC7224611 | biostudies-literature
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