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ProteomicsProteome profiling of whole plasma and plasma-derived extracellular vesicles facilitates the detection of tissue biomarkers in the non-obese diabetic (NOD) mouse
Using plasma samples collected from pre-diabetic non-obese diabetic (NOD) mice (an experimental model of T1D) we performed parallel analysis of whole plasma samples and plasma-derived extracellular vesicle (EV) fractions using mass spectrometry (MS). Whole plasma samples were depleted of abundant pr...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-20 | PXD033867 | Pride
Biomarkers  extracellular vesicles  exosomes  mass spectrometry  mouse  non-obese diabetic (nod) mouse  plasma  type 1 diabetes 
ProteomicsMULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK
Many polyphenols, such as hydroxytyrosol (HT), have been recognized for their antioxidant and cardiovascular (CV) health benefits. To address the efficacy of HT, the present study aimed to identify the relevant mechanisms, associated with high-CV risk. Plasma unbiased multi-omics data were compared ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-07-01 | PXD060820 | Pride
Human plasma Hydroxytyrosol Mouse ev enriched plasma 
ProteomicsMouse Plasma Extracellular Vesicle Proteome
Regular physical activity elicits broad physiological adaptations, yet the molecular mechanisms underlying systemic responses remain incompletely understood. Circulating extracellular vesicles (EVs) have emerged as key mediators of interorgan communication, carrying protein cargo that may reflect an...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD064533 | Pride
Exercise Mouse Extracellular vesicles Plasma Proteomics Lc-ms/ms 
ProteomicsExpanding glycopeptide identification with Match-Between-Glycans (MBG) in FragPipe
Glycosylation is one of the most important, but also most complex, post-translational modifications of proteins. Mass spectrometry-based glycoproteomics analysis offers a powerful approach to explore the fundamental roles of glycosylation, but achieving sufficient fragmentation for glycopeptide assi...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-01 | PXD074575 | Pride
Human plasma  glycoproteomics  n-glycopeptides  pasef  timstof  msfragger-glyco  fragpipe  ion mobility 
UnknownProteome profiling of whole plasma and plasma-derived extracellular vesicles facilitates the detection of tissue biomarkers in the non-obese diabetic mouse.
Not available
S-EPMC9563222 | biostudies-literature
GenomicsIntegration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model [EV ncRNA-Seq]
Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model [EV ncRNA-Seq]
PRJNA1470741 | ENA
TranscriptomicsOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
ORGANISM(S): Homo sapiens 
2016-10-05 | E-MTAB-4560 | biostudies-arrayexpress
ProteomicsTemporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.
Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-21 | PXD062615 | Pride
Protein cargo Extracellular vesicles Macrophages Burn injury Thermal injury Burn injury 
ProteomicsExtracellular Vesicles from Adiponectin-Deficient Mice Mediate Skeletal Muscle Metabolic Dysfunction and Insulin Resistance
Adiponectin regulates systemic metabolism and enhances extracellular vesicle (EV) biogenesis, but the impact of adiponectin deficiency on circulating EV composition and their impact on muscle metabolism remains unclear. Here, we integrated proteomic analyses of plasma EVs from wild-type (WT) and adi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-08-03 | PXD070917 | Pride
Metabolism Adiponectin Proteomics Extracellular vesicles Skeletal muscle 
ProteomicsMouse Exercise & Sedentary Extracellular Vesicles
In our study, we conducted a comprehensive proteomic analysis on small extracellular vesicles (sEVs) and exercise-induced extracellular vesicles (eEVs) to investigate their potential roles and protein cargos that may be pertinent to neurodegenerative diseases, particularly Alzheimer's Disease (AD). ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-06 | PXD050696 | Pride
Exactive hf Exercise Metabolism Mouse Extracellular vesicles 
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