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MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
MetabolomicsGut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, an...

2026-01-16 | MTBLS13700 | MetaboLights
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
TranscriptomicsTranscription profiling of mouse embryonic fibroblast cultures - induction of pluripotent-like cells derived from MEF by defined factors
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of their nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about the factors that induce this reprogramming. Here we show that the combination of four factors, Oct3/4, Sox2, c-Myc...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5259 | biostudies-arrayexpress
ProteomicsSecretome analysis of mouse fibroblast
Fibrillin-1, an extracellular matrix (ECM) protein encoded by FBN1 gene, serves as the microfibril scaffold crucial for elastic fiber formation and homeostasis in pliable tissue such as the skin. Besides causing Marfan syndrome, some mutations in FBN1 result in scleroderma, marked by hardened and th...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-11 | PXD052580 | JPOST Repository
ProteomicsHypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice
Dataset Pertaining to the proteome changes of the cardiac fibroblast in the whole cell, exosome, and soluble secretome.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-08-12 | MSV000080038 | MassIVE
ProteomicsNRF2-dependent ECM - Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome
Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. ECM was isolated from WT and NRF2-/- mouse fibroblasts and analyzed by label-free quantification.
ORGANISM(S): Mus musculus (Mouse) 
2018-07-23 | PXD007999 | Pride
Ecm Mouse Nrf2 Matrisome Fibroblast Senescence 
ProteomicsComparative analysis of mouse muscles types
The dataset presents FASP- and LC-MS/MS-based analysis of whole lysates of tree types of mouse muscle tissue: white and red muscle fibers and heart muscle. The measurements were performed using five biological replicates for each tissue type. The dataset cover 7200 proteins. The data were used for ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084934 | MassIVE
MetabolomicsMetabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells
Not available
ORGANISM(S): Mus musculus 
ST000003 | MetabolomicsWorkbench
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