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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14243 | MetaboLights
MetabolomicsSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
Abstract Aim: Circulating triglyceride and triglyceride-rich lipoprotein (TRL) accumulation is increasingly recognized as a residual atherosclerotic risk, but their specific effect in cardiac remodeling and heart failure (HF) remain largely unexplored. Here we investigated this issue in Gpihbp1 knoc...
2026-06-11 | MTBLS14749 | MetaboLights
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14245 | MetaboLights
TranscriptomicsExpression data from mouse heart deficient of HDAC3
Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relati...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-31251 | biostudies-arrayexpress
ProteomicsMouse mitochondrial CLPP substrate identification
Identification ofputative ClpXP substrates by combination of proteome analysis and TAILS N termini profiling from wt and ClpP-deficient mouse heart mitochondria, combined with substrate trapping using catalytically inactive ClpP expressed in MEF cell culture. This dataset provides the preTAILS prote...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD018194 | Pride
Clpxp Mouse heart Mitochondria 
Proteomicsmitochondria cross-linking mass spectrometry
We performed cross-linking mass spectrometry experiments on intact mitochondria isolated from mouse heart in two conditions, native-state and high-salt treatment to disrupt electrostatic interactions. Both conditions were provided in biological replicates.
ORGANISM(S): Mus musculus (Mouse) 
2017-12-11 | PXD006816 | Pride
Mouse Heart Cross-linking mass spectrometry Mitochondria 
ProteomicsHeart Mitochondrial Proteome - The Failing Heart Relies on Ketone Bodies as a Fuel
Isolation of Heart Mitochondria of defined stages of pressure overload-induced heart failure in mice
ORGANISM(S): Mus musculus (Mouse) 
2016-05-09 | PXD001820 | Pride
Mouse heart mitochondria 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
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