Sort   by:  
 Page size 
MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
MetabolomicsSuccinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

Succinate is implicated in rheumatoid arthritis (RA) and other inflammatory diseases via its receptor, G protein-coupled receptor 91 (GPR91). Despite its therapeutic potential, conflicting reports on its inflammatory roles have hindered GPR91-targeted treatm...

2026-02-05 | MTBLS13828 | MetaboLights
MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF-and M-CSF-differentiated mouse macrophages

Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions. In vitro macrophage models could be derived from ...

2023-09-19 | MTBLS6502 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate
Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirul...
2026-06-30 | MTBLS14903 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate
Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirul...
2026-06-30 | MTBLS14901 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate

Background & Aims:

Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesize...

2026-01-11 | MTBLS13653 | MetaboLights
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate

Background & Aims:

Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesize...

2026-01-12 | MTBLS13657 | MetaboLights
TranscriptomicsMacrophage epoxygenase determines a pro-fibrotic transcriptomesignature
Epoxygenases belong to the cytochrome P450 family and they generate epoxyeicosatrienoic acids (EETs) known to have anti-inflammatory effects but little is known about their role in macrophage function. By high-throughput sequencing of RNA (RNA-seq) in primary macrophages derived fromrodents and huma...
ORGANISM(S): Rattus norvegicus 
2015-02-10 | E-GEOD-65715 | biostudies-arrayexpress
ProteomicsProteomics of necrotic granulomas in lungs of C3HeB/FeJ mice infected with M. tuberculosis
C3heB/FeJ mice were infected with M. tuberculosis to form necrotic granulomatous lesions. FFPE samples of infected lungs with granulomas were microdissected into three distinct regions, Caseum, foamy macrophage, and Cell. Proteins were extracted from microdissected samples, followed by LC-MS/MS.
ORGANISM(S): Mus Musculus (mouse) 
2022-09-06 | PXD030088 | JPOST Repository
MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
Sort   by:  
 Page size