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TranscriptomicsTranscriptome profiling of severe spinal muscular atrophy mouse embryonic stem cell-derived motor neurons
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected ...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-56284 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ of Satb1-knockdown in dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse dopaminergic neurons from the mouse mid-brain, with AAV1 injections using a Satb1 shRNA-EGFP construct or a scrambed shRNA-EGFP construct Murine midbrain dopaminergic neurons with Satb1 shRNA treatment or scrambled control
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-70133 | biostudies-arrayexpress
ProteomicsPhactr1/PP1 phosphatase substrates in mouse primary neurons
Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD019882 | Pride
Neurons Phosphatase Mouse Phactr1 
TranscriptomicsWhole genome transcriptome analysis identifies indices of fast and slow disease progression in two ALS mouse models
Microarray analysis has been applied to the study of ALS in order to investigate gene expression in whole spinal cord homogenates of SOD1 G93A mice and human ALS cases, although the massive presence of glial cells and inflammatory factors has made it difficult to define which gene expression changes...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-46298 | biostudies-arrayexpress
TranscriptomicsAn intricate interplay between astrocytes and motor neurons in ALS
Amyotrophic Lateral Sclerosis (ALS) results from the selective and progressive degeneration of motor neurons. Although the underlying disease mechanisms remain unknown, glial cells have been implicated in ALS disease progression. Here we examine the effects of glial cell/motor neuron interactions on...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-43879 | biostudies-arrayexpress
TranscriptomicsAltered Distributions of SMN-containing GEMs and Mitochondria in Motor Neurons of TDP-43 transgenic Mice
TDP-43, a DNA/RNA binding protein involved in RNA transcription and splicing has been associated with the pathophysiology of neurodegenerative diseases, including ALS. However, the function of TDP-43 in motor neurons remains undefined. Here, we employ both gain- and loss-of-function approaches to de...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse FACS-purified cortical projection neurons using Affymetrix 430 2.0 microarrays
3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting (FACS) at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005) and Molyneaux, BJ et al (2009). The hybridization cocktails use...
ORGANISM(S): Mus musculus 
2009-10-09 | E-GEOD-17783 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of spinal and bulbar muscular atrophy cultured embryonic motor neurons
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s Disease, is a slowly progressive adult-onset neuromuscular disease which results from a polyglutamine (polyQ) encoding CAG repeat expansion within the androgen receptor gene (AR). Despite the ubiquitous expression of the androgen rec...
ORGANISM(S): Mus musculus 
2019-05-02 | E-MTAB-6986 | biostudies-arrayexpress
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