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MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
TranscriptomicsTranscription profiling of immature germinal vesicle stage oocytes with mature metaphase II oocytes to identify and characterize the changed and stable transcripts during mouse oocyte maturation.
There is massive destruction of transcripts during maturation of mouse oocytes. The objective of this project was to identify and characterize the transcripts that are degraded versus those that are stable during the transcriptionally silent germinal vesicle (GV)-stage to metaphase II (MII)-stage t...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5668 | biostudies-arrayexpress
ProteomicsProteomic-based identification of oocyte maturation-related proteins in mouse GV oocytes
In this study, we applied 1D SDS-PAGE and RP-LC-MS/MS to investigate the proteins stored in GV mouse oocytes. This high-performance strategy allowed us to define a set of 1405 different mouse GV oocyte proteins. It is confirmed that this study will help us to understand the diverse biological proces...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-17 | PXD014314 | Pride
Mouse Gv oocytes Lc-ms/ms 
Proteomicsquantitative proteomic analysis of mouse oocyte of different chromatin configurations
Chromatin configuration serves as a principal indicator of GV (germinal vesicle)-stage oocyte quality. In this study, a quantitative proteomics method was applied to investigate the the underlying mechanisms governing the chromatin configuration.
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD048173 | Pride
Chromatin configuration Mouse Tmt Oocyte 
TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
TranscriptomicsOocyte-expressed Yes-associated Protein (YAP) is a Key Activator of the Early Zygotic Genome in Mouse
We generated maternal and paternal mouse models with Yap1-deletion, and elucidated the function of maternal YAP in zygotic genome activation. RNA sequencing with 2 WT oocyte samples at GV stage, 2 YAP-/- oocyte samples at GV stage, 1 WT embryo samples at 4cell stage, 1 YAP-/- embryo samples at at 4-...
ORGANISM(S): Mus musculus 
2016-02-28 | E-GEOD-74344 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse, bovine and xenopus germinal vesicle stage oocytes reveals a high degree of conservation among species
Comparative analysis of bovine, mouse and xenopus oocyte transcript profiles. The results from bovine and xenopus germinal vesicle stage oocytes in this experiment were compared to previously-published microarray data on preimplantation development in the mouse (Carter 2003).
ORGANISM(S): Xenopus laevis 
2008-02-01 | E-MEXP-1339 | biostudies-arrayexpress
ProteomicsMouse aging oocyte proteome comparison
Here we asked if oocyte proteomes are representative of the transcriptomes, how the abundance of specific genes’ mRNA and protein responds to maternal aging, and if oocyte aging presents the features characteristic of somatic aging. To address these questions on the proteomic level, we employed stab...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-14 | PXD000512 | Pride
Mus musculus Embryonal carcinoma cells Spike-in Silac Oocyte 
ProteomicsProtein profiling of mouse fully-grown oocyte
To verify the Ribo-seq data of mouse oocyte, we performed MS/MS on mouse fully-grown oocytes. And the results show that our Ribo-seq data well reflect the proteomic dynamics in the fully grown oocytes.
ORGANISM(S): Mus musculus (Mouse) 
2022-03-14 | PXD032229 | Pride
Mouse oocyte proteomic 
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