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MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
TranscriptomicsExpression variation in the mouse retina
Expression analysis of multiple mouse strains across two developmental timepoints to determine both strain specific and temporal expression of genes in the mouse retina A total of 29 retinas were collected from 15 mice of each strain at similar time points during the day. Equimolar amounts of RNA is...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-24512 | biostudies-arrayexpress
ProteomicsThe Comprehensive Mouse Retina Proteome
A comprehensive mouse retina proteome including six development stages (E13.5, E15.5, P0, P6, and P21, mixed sample).
ORGANISM(S): Mus musculus (Mouse) 
2021-07-11 | PXD023439 | Pride
Retina Mouse Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse developing and mature Nrl -/- retina against wild type controls
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a co...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-8972 | biostudies-arrayexpress
ProteomicsThe Comprehensive Mouse Retina Proteome
Diverse groups of proteins play integral roles in both the physiology and pathophysiology of the mouse retina. A comprehensive mouse retina proteome has been developed using a discovery-based proteomic approach.
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD009909 | Pride
Mouse retina proteome Swiss-webster nd4 
ProteomicsThe Comprehensive Mouse Retina PhosphoProteome
Diverse groups of proteins play integral roles in both the physiology and pathophysiology of the mouse retina. A comprehensive mouse retina phosphoproteome has been developed using a discovery-based proteomic approach in conjunction with an enrichment procedure for phosphopeptides.
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD009981 | Pride
Mouse retina proteome Phosphoproteome Swiss-webster nd4 
TranscriptomicsRNA-Seq of mouse eye and retina tissues from wild type and Nrl transcription factor knockout mice
The initial aim of this work was to understand the pathophysiology of Enhanced S-cone Syndrome (ESCS) that leads to retinal degeneration. Although ESCS was identified in humans decades ago and since then the causative genes have been elucidated, our understanding of the accompanying retinal degenera...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29752 | biostudies-arrayexpress
ProteomicsProteomic profiling of embryonic retina to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefor...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD039490 | Pride
Gene discovery Proteome Embryogenesis Retina Mass spectrometry Isyte Development 
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