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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
MetabolomicsProbiotics alleviated heat stress-induced spermatogenesis dysfunction by remodeling gut microbiota and producing arginine and pantothenic acid

BACKGROUND: Large-scale farms struggle to effectively address summer heat stress (HS) in dairy goats, which impairs spermatogenesis and reduces reproductive performance by compromising gut and reproductive organ health in male animals. Although Clostridium butyricum (CB) and Enterococcus faecium ...

2025-07-31 | MTBLS12573 | MetaboLights
MetabolomicsRed-Fleshed Apple Anthocyanin Extracts Attenuate Male Reproductive System Dysfunction Caused by Busulfan in Mice (Mouse blood plasma; UPLC-MS/MS assays)

In this research, we analyzed the effect of oral administration of red-fleshed apple anthocyanin extract (RAAE) on busulfan-treated mice. At first, we showed that the most abundant component in RAAE was cyanidin 3-O-galactoside. To determine the effect of RAAE, mice were divided into control and ...

2021-06-07 | MTBLS2782 | MetaboLights
Proteomics,MultiomicsComplementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproduction
The mammalian Y chromosome plays a critical role in spermatogenesis. However, the exact functions of each gene in the Y chromosome have not been completely elucidated, partly owing to difficulties in gene targeting analysis of the Y chromosome. Zfy was first proposed to be a sex determination factor...
ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088) 
2016-11-24 | MSV000080355 | MassIVE
ProteomicsStudying the role of RPL39L in mouse spermatogenesis
Proteostasis regulated by RPL39L maintains mouse spermatogenesis
ORGANISM(S): Mus Musculus 
PXD029274 |
TranscriptomicsRNA-Seq and RNA Polymerase II ChIP-Seq of mouse spermatogenesis
To characterize gene expression in spermatogenesis we sequenced eight mRNA samples from testes of juvenile mice aged between 6 and 38 days post partum. We then classified gene expression profiles and found over 1,000 meiotically-expressed protein-coding genes that have not been previously reported i...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-44346 | biostudies-arrayexpress
TranscriptomicsTranscriptomic sequencing of the murine testis during the first wave of spermatogenesis
Our experimental design includes samples at different time points during the first wave of spermatogenesis. Each time point corresponds to specific cell content in the testis. First time point is post natal day (PND) 7, when only somatic cells and spermatogonia are present in the testis. Thereafter ...
ORGANISM(S): Mus musculus 
2013-04-29 | E-GEOD-39970 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of mouse germ cells
Spermatogenesis is a recurring differentiation process that results in the production of male gametes within the testes. During this process, spermatogonial stem cells differentiate to form spermatocytes, which undergo two rounds of meiotic division to form haploid spermatids. Throughout spermiogene...
ORGANISM(S): Mus musculus 
2019-01-25 | E-MTAB-6946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spermatogenesis in juvenile mouse testis and analysis of four germ cell deficient mouse models, time series
Temporal study of the first wave of spermatogenesis in juvenile mouse testis and analysis of four germ cell deficient mouse models.
A series of purified testis cell-types (McCarrey libraries)constituting a focussed gene set was exploited to examine gene expression in prepubertal mouse testis. T...
ORGANISM(S): Mus musculus 
2006-08-10 | E-MEXP-571 | biostudies-arrayexpress
TranscriptomicsThe dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately with developing germ cells. They not only provide physical and nutritional support but also secrete factors essential to the complex developmental processes of germ cell proliferation and differentiation. T...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-59698 | biostudies-arrayexpress
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