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MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
TranscriptomicsGene expression profile of developing adipose tissue in vivo
Obesity is characterized by an increase in the size and the number of adipocytes. However, the mechanisms responsible for the formation of adipocytes during development and the molecular mechanisms regulating their increase and maintenance in adulthood are poorly understood. Here, we report the use...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29502 | biostudies-arrayexpress
ProteomicsComprehensive Map and Functional Annotation of the Mouse White Adipose Tissue Proteome
Our data provide a large dataset of the normal mouse WAT proteome, which can be used as a baseline reference for further study.
ORGANISM(S): Mus Musculus 
2019-02-14 | PXD020169 |
TranscriptomicsTranscription profiling of mouse white adipose tissue
Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT). The early transcriptome changes in WAT were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses bet...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8679 | biostudies-arrayexpress
TranscriptomicsLR11 knockout in BAT and WAT
To study the gene expression profiles of brown (BAT) and white (WAT) adipose tissues in wild type and LR11-deficeint mice. The four RNA sources, WT scWAT, Lr11 -/- scWAT, WT BAT and Lr11 -/- BAT, were prepared from subcutaneous WAT and BAT from wild-type mice and Lr11 -/- mice, respectively (n=3 eac...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-69117 | biostudies-arrayexpress
TranscriptomicsNuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance
We demonstrated that RORa-deficient staggerer mice (RORasg/sg) fed with a high fat diet (HFD) showed reduced adiposity and hepatic triglyceride levels compared to wild type (WT) littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resis...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-23736 | biostudies-arrayexpress
TranscriptomicsIdentification of CD44 downstream target genes
CD44 expression has been shown to be enhanced in the liver and white adipose tissue (WAT) during obesity, suggesting a possible regulatory role for CD44 in metabolic syndrome. To study this hypothesis, we compared the gene expression profiles in liver and in WAT between WT and CD44 knockout (CD44KO)...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-43104 | biostudies-arrayexpress
TranscriptomicsISR target genes in WAT and BAT of mAP::Fv2E-PERK
To identify the target genes of integrated stress reponse (ISR) in WAT and BAT, we have employed whole genome microarray expression in WAT and BAT specific Fv2E-PERK transgenic mice. The mAP::Fv2E-PERK transgenic mice were injected by AP20187 or mock.
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-49645 | biostudies-arrayexpress
TranscriptomicsDEPTOR cell-autonomously promotes adipogenesis and associates with obesity
An understanding of the mechanisms regulating white adipose tissue (WAT) formation is key for developing of new tools to treat obesity and its related diseases. Here, we identify DEPTOR as a positive regulator of adipogenesis whose expression is associated with obesity. In a polygenic mouse model of...
ORGANISM(S): Mus musculus 
2012-08-14 | E-GEOD-38321 | biostudies-arrayexpress
UnknownA <i>Wars2</i> mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning.
Not available
S-EPMC9452902 | biostudies-literature
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