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ProteomicsAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Genetic association links DIORA1 to numerous autoimmune rheumatic diseases including systemic lupus erythematous, Sjögren's disease, myositis, scleroderma and rheumatoid arthritis, but its cellular function remains unknown. Here, we identify the MRCK kinase family as DIORA1 interactors. MRCK kinases...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD064939 | Pride
Autoimmunity Epithelial-mesenchymal transition (emt) Rho gtpase signaling Diora1 Mrck kinases Kinase inhibitory motif (kim) Cancer Cell motility Cytoskeleton Fam167a 
GenomicsAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
PRJNA1274935 | ENA
TranscriptomicsAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Genetic association links DIORA1 to numerous autoimmune rheumatic diseases, including systemic lupus erythematosus, Sjögren's disease, rheumatoid arthritis, polymyositis and systemic sclerosis. However, its cellular function has remained unknown. Here, we identify the MRCK family of serine/threonine...
ORGANISM(S): Homo sapiens 
2025-09-08 | GSE299540 | GEO
UnknownOpportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics.
Not available
S-EPMC9954052 | biostudies-literature
UnknownAutoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility.
Not available
S-EPMC12519202 | biostudies-literature
UnknownDiscovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Not available
S-EPMC5901721 | biostudies-literature
UnknownCharacterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases.
Not available
S-EPMC10458458 | biostudies-literature
UnknownA novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Not available
S-EPMC4195943 | biostudies-literature
UnknownA novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion.
Not available
S-EPMC4182185 | biostudies-literature
UnknownPAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.
Not available
S-EPMC1134783 | biostudies-literature
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