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The purpose of this project is to determine changes in proteins and signaling pathways in injured tendons of C57BL/6j and MRL/MpJ mice. The MRL.MpJ mice have been reported to have a strong repair ability compared to that of C57BL/6j mice. Identifying signaling pathways in MRL/MpJ tendons that are di...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-16 | PXD057712 | Pride
Epigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. In order to investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms an...
ORGANISM(S): Mus musculus 
RNA Sequencing Facilitates Quantitative Analysis of Lupus (MRL/lpr) and Control(MRL/mpj)Mouse Microglia Tanscriptomes
Comparative Transcriptomics of STR/ort, C57BL/6 and MRL/MpJ Knee Joints
Animal models have enhanced our understanding of the pathogenesis of autoimmune diseases. For these models, genetically identical, inbred mice have commonly been used. Different inbred mouse strains, however, show a high variability in disease manifestation. Identifying the factors that influence th...
ORGANISM(S): Mus musculus 
Differential response to rotator cuff tear in C57BL/6J mice and MRL/MpJ mice
Cryptorchidism and scrotal heating result in abnormal spermatogenesis but the mechanism(s) proscribing this temperature sensitivity are unknown. It was previously reported that the AKR/N or MRL/MpJ-+/+ mouse testis is more heat resistant than the testis from the C57BL/6 strain. We have attempted to ...
ORGANISM(S): Mus musculus 
2008-11-01 | GSE12950 | GEO
Epigenetic regulation plays essential role in cell differentiation and dedifferentiation, which are the intrinsic processes involved in regeneration. In order to investigate the epigenetic basis of regeneration capacity, we choose DNA methylation as one of the most important epigenetic mechanisms an...
ORGANISM(S): Mus musculus 
2013-08-20 | GSE49221 | GEO
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