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TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells
We found that CFIm68, a mRNA cleavage and polyadenylation factor implicated for alternative polyadenylation site choice, was co-purified with Thoc5, a component of human THO/TREX. Microarray analysis using human HeLa cells reveals knockdown of Thoc5 affects the expression of a subset of non-heat sho...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-42327 | biostudies-arrayexpress
TranscriptomicsTHOC5 controls 3M-BM-4end-processing of immediate early genes via interaction with CPSF100
Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsic signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that TH...
ORGANISM(S): Mus musculus 
2014-11-03 | E-GEOD-59561 | biostudies-arrayexpress
ProteomicsTHOC5 complexes with other proteins (DDX5, DDX17 and CDK12) essential in primitive cell survival to regulate R loop structures and RNA elongation rate.
THOC5, a member of the THO complex, is essential for the 3´processing of some inducible genes, the export of a subset of genes and stem cell self-renewal. Utilising nanopore mRNA-sequencing we show that when THOC5 is depleted 50% of mRNAs undergo altered 3´end cleavage. Further, THOC5 depletion lead...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD035092 | Pride
Rna sequencing using nanopore technology Pol ii elongation rate Mrna export protein thoc5 R-loop 
TranscriptomicsThe THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (microarray)
Embryonic stem cell (ESC) self-renewal and differentiation are governed by a broad-ranging regulatory network. Although the transcriptional regulatory mechanisms involved have been investigated extensively, post-transcriptional regulation is still poorly understood. Here we describe a critical role ...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-51496 | biostudies-arrayexpress
UnknownTHOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation.
Not available
S-EPMC3899923 | biostudies-literature
TranscriptomicsIdentification of novel biomarkers and potential target molecules of human hepatocellular carcinoma using THOC5, a member of the transcription/export (TREX) complex, depleted system
Hepatocellular carcinoma (HCC) is a frequent cancer with poor prognosis and with limited possibilities for anti-cancer treatment. Evidence has recently accumulated suggesting that multiple signaling pathways are activated in human cancer. It has been recently shown by exosome sequencing of HCC that...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-70178 | biostudies-arrayexpress
UnknownAdaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
Not available
S-EPMC2657587 | biostudies-literature
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | GSE41170 | GEO
TranscriptomicsThe THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (RNA-IP)
Embryonic stem cell (ESC) self-renewal and differentiation is governed by a comprehensive regulatory network. Although the transcriptional regulation has been extensively investigated, post-transcriptional mechanisms controlling the ESC state are poorly understood. Here we describe a critical role o...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-48436 | biostudies-arrayexpress
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