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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
MetabolomicsCell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and c...

2026-02-28 | MTBLS13927 | MetaboLights
ProteomicsIdentification of mRNA processing complexes bound to histone H2A.2 3’ untranslated region
Processing of 3’ untranslated region (3’-UTR) of precursor messenger RNAs (pre-mRNA) is a fundamental step in mRNA maturation, where the mRNA transcript is cleaved at a specific site, located downstream the open reading frame of the encoded gene. The position of the cleavage site is determined by ci...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-12-09 | PXD034984 | Pride
Pre-mrna processing Processing factors Nanolc-ms/ms Mrna maturation 
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
TranscriptomicsBudding yeast mRNA export and processing factors
This SuperSeries is composed of the following subset Series: GSE30703: Budding yeast mRNA poly( A) site mapping GSE30705: Budding yeast mRNA export and processing factor localization Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30706 | biostudies-arrayexpress
TranscriptomicsNon-essential mRNA processing factors
Set of experiments done on yeast deletion strains of various non-essential mRNA processing factors. Keywords = splicing
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-35 | biostudies-arrayexpress
ProteomicsIdentification of human mRNA processing complexes bound to histone H2A.2 3’ untranslated region
Processing of 3’ untranslated region (3’-UTR) of precursor messenger RNAs (pre-mRNA) is a fundamental step in mRNA maturation, where the mRNA transcript is cleaved at a specific site, located downstream the open reading frame of the encoded gene. The position of the cleavage site is determined by ci...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD027636 | Pride
3’-utr Mrnas Nanolc-ms/ms 3’ pre-mrna processing complexes 
TranscriptomicsBudding yeast mRNA export and processing factor localization
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra1 influences cleavage-polyadenylation. Yra1 competes with the CF1A subunit, Clp1, for binding to Pcf...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30705 | biostudies-arrayexpress
TranscriptomicsIdentification of allele-specific alternative mRNA processing via transcriptome sequencing
Establishing the functional roles of genetic variants remains a significant challenge in the post-genomic era. Here, we present a method, allele-specific alternative mRNA processing (ASARP), to identify genetically influenced mRNA processing events using transcriptome sequencing (RNA-Seq) data. The ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-29738 | biostudies-arrayexpress
GenomicsMediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its Med23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recomb...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-33887 | biostudies-arrayexpress
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