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ProteomicsImmunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes
Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic resistance no clinically approved vaccine against Listeria is available. To identify antigens for this bacterial pathogen that can be encoded i...
ORGANISM(S): Homo sapiens (Human) Listeria monocytogenes EGD 
2022-09-26 | PXD031451 | Pride
Tmt Fusion lumos Listeria monocytogenes Hela Immunopeptidomics Epitope discovery Bacterial infection Label-free Q exactive hf Hct-116 Antigen discovery Vaccine development 
ProteomicsDeep, Unbiased and Quantitative mass spectrometry-based plasma proteome analysis of personalized response to mRNA COVID-19 vaccine
Global efforts against COVID-19 have vaccinated a significant portion of the world population in recent years. Combating the COVID-19 pandemic with mRNA vaccines playinged a pivotal role in global immunization effort. However, individual responses to these vaccines vary, leading to diverse vaccinati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-18 | MSV000094352 | MassIVE
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections.
The objective of this study is to: 1) Characterize the immune responsiveness to administration of non-live vaccines in three cohorts of healthy adult subjects through the analysis of blood leukocytes transcriptional profiles. 2) Validate whole blood transcriptional profiles generated from standard 3...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-30101 | biostudies-arrayexpress
ProteomicsPytheas SARS-CoV-2 spike protein mRNA sample analysis
Mass spectrometry remains an important method for analysis of modified nucleosides ubiquitously present in cellular RNAs, in particular for ribosomal and transfer RNAs that play crucial roles in mRNA translation and decoding. Furthermore, modifications have effect on the lifetimes of nucleic acids i...
ORGANISM(S): Escherichia coli 
2022-05-04 | PXD030845 | Pride
Isotope labeling Sars-cov-2 spike protein Pytheas Mrna 
ProteomicsProteome and phospho-proteome profiling of mRNA vaccine-perturbated on LF chips
We profiled the proteome and phospho-proteome of human LF chips after perturbation of two different types of mRNA vaccines.
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD056699 | Pride
Tmt Proteomic Mrna vaccine 
TranscriptomicsGenome-wide profiling of whole blood from healthy adult volunteers before and after receiving non-live vaccines including seasonal influenza or pneumococcal vaccine or placebo (saline) injections II
The objective of this study is to: 1) Characterize the immune responsiveness to administration of non-live vaccines in three cohorts of healthy adult subjects through the analysis of blood leukocytes transcriptional profiles. 2) Validate whole blood transcriptional profiles generated from standard 3...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-48762 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA and B cell receptor profiling of B cell response to SARS-CoV-2 vaccination
We generated single-cell transcriptomic and BCR sequencing data of B cells from peripheral blood samples taken from a SARS-CoV-2-antigen-naive cohort being vaccinated with the SARS-CoV-2 mRNA-1273 vaccine. Blood samples were collected at the baseline timepoint D-1 (i.e. one day prior to the initial ...
ORGANISM(S): Homo sapiens 
2026-05-08 | E-MTAB-16531 | biostudies-arrayexpress
GenomicsResponse to mRNA vaccine BNT162b2 in hemodialysis patients
Response to mRNA vaccine BNT162b2 in hemodialysis patients
PRJNA863278 | ENA
GenomicsPrototype LNP-mRNA vaccine candidates [SC_RNAseq]
Prototype LNP-mRNA vaccine candidates [SC_RNAseq]
PRJNA853803 | ENA
TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
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