GEnerating the the gene expression profil of MRP8/MRP14-stimulated HMEC monolayer. Experiment Overall Design: 4 independent experiments Experiment Overall Design: HMEC-1 monolayer were left untreated or stimulated for 6h with 200 µg/ml MRP8/MRP14.
The alarmins myeloid-related protein (MRP) 8 and MRP14 are the dominant cytoplasmic proteins in phagocytes. After release by activated phagocytes extracellular MRP8/MRP14 complexes promote inflammation in many diseases, including infections, allergies, autoimmune diseases, rheumatoid arthritis or in...
Purpose: The goal of this study is to examine how the specific loss of TGFbR2 (under Mrp8 promoter for Cre recombinase) changes the transcriptome of neutrophils in the lung compared to their wildtype littermates.
The alarmins myeloid-related protein (MRP) 8 and MRP14 are the dominant cytoplasmic proteins in phagocytes. After release by activated phagocytes extracellular MRP8/MRP14 complexes promote inflammation in many diseases, including infections, allergies, autoimmune diseases, rheumatoid arthritis or in...