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ProteomicsCytokine Priming Enhances the Antifibrotic Effects of Mesenchymal Stromal Cells Conditioned Medium Via Fibrogenic Myofibroblasts Elimination and Extracellular Matrix Degradation.
Fibrosis is a pathological scarring process characterized by persistent myofibroblasts activation with excessive accumulation of extracellular matrix (ECM). Fibrotic disorders represent an increasing burden of disease-associated morbidity and mortality worldwide for which there are limited therapeut...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051586 | Pride
Msc Myofibroblasts Multipotent mesenchymal stromal cells Fibrosis Conditioned medium Extracellular matrix 
UnknownPersistent tailoring of MSC activation through genetic priming.
Not available
S-EPMC11396059 | biostudies-literature
UnknownPersistent tailoring of MSC activation through genetic priming.
Not available
S-EPMC10871228 | biostudies-literature
ProteomicsProteomic analysis of Wharton's jelly derived mesenchymal stem cell (WJ-MSC) secretome primed with inflammatory proteins
The immunomodulatory potential of mesenchymal stromal cells (MSCs) has led to their widespread exploration in treating various inflammatory conditions. MSCs sourced from adult tissues such as bone marrow, Wharton’s jelly, and adipose tissue are multipotent and exhibit strong stemness characteristics...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD064143 | Pride
Secretome Mesenchymal stem cell Priming 
UnknownIL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration.
Not available
S-EPMC11309046 | biostudies-literature
ProteomicsProteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) are a heterogeneous population of multipotent cells that can be obtained from various tissues, such as dental pulp, adipose tissue, bone marrow and placenta. MSCs have gained importance in the field of regenerative medicine because of their promising role in cel...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD052445 | Pride
Msc priming Msc therapeutic properties Proteomic analysis Msc paracrine effects Placenta-derived mesenchymal stromal/stem cells Ifn-γ priming Hypoxia priming 
TranscriptomicsSingle-cell RNA-seq of bone marrow-derived mesenchymal stem cells reveals unique profiles of lineage priming
The plasticity and immunomodulatory capacity of mesenchymal stem cells (MSCs) have spurred clinical use in recent years. However, clinical outcomes vary and many ascribe inconsistency to the tissue source of MSCs. Yet unconsidered is the extent of heterogeneity of individual MSCs from a given tiss...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-70930 | biostudies-arrayexpress
ProteomicsProteomics analysis of exosomes derived from human umbilical cord mesenchymal stem cells
Mesenchymal stem cell-derived exosomes (MSC-Exos), noted for their minimal immunogenicity and robust immunomodulatory potential, have emerged as key regulators of immune cell fate. Nevertheless, a comprehensive understanding of their global impact on human NK cell proliferation and effector function...
ORGANISM(S): Homo sapiens (Human) 
2026-04-16 | PXD073707 | Pride
UnknownBolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media.
Not available
S-EPMC9761620 | biostudies-literature
GenomicsReal-time quantitative PCR analysis of human mesenchymal stromal (MSC) cells extracellular vesicles (EV)
Real-time quantitative PCR analysis of human mesenchymal stromal (MSC) cells extracellular vesicles (EV)
PRJNA659509 | ENA
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