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ProteomicsMembrane proteome profile of MSI-tumor organoids exposed to conditioned media of MSI and MSS-tumor organoids
MSI-tumor organoids were previously stimulated with 200 ng/mL IFNγ for 24 hours. Then, organoids were dissociated into single cells using TrypLE express and resuspended in conditioned media. Cells were seeded in a 24-well plate and incubated for 24 hours at 37°C. After incubation, tumor cells were c...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD066343 | Pride
Protein signature. Mass spectrometry (ms) Msi-tumor organoids Membrane proteomics 
UnknownMulti-omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability.
Not available
S-EPMC10315803 | biostudies-literature
UnknownOrganoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer.
Not available
S-EPMC10516605 | biostudies-literature
ProteomicsIntra-patient clonal diversity in HLA class I peptide ligand presentation
Tumor heterogeneity results from clonal diversity and evolutionary selection, and is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug resistant cells, and tumor-specific HLA peptide ligands on the cell surface are promising leads to invoke such t...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD016582 | Pride
Hla class i peptide ligands  colorectal cancer  tumor heterogeneity  patient-derived organoids  mass spectrometry  affinity proteomics 
UnknownWhole genome characterization of patient-derived lung cancer organoids.
Not available
S-EPMC12683417 | biostudies-literature
UnknownProinflammatory cytokines modify Ca<sup>2+</sup> signaling and induce an apoptotic lipidome in murine small intestinal organoids.
Not available
S-EPMC12920202 | biostudies-literature
UnknownMALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids.
Not available
S-EPMC5839975 | biostudies-literature
GenomicsIdentification of neoantigen from MSI-CRC patient derived organoids and its application for targeting by autologous T cells
Targeting neoantigens expressed only by tumor cells enable tumor destruction without unexpected damages to healthy tissues. Here, we identified neoantigens from microsatellite instable (MSI) colorectal cancer (CRC) patient-derived organoids by genomics and immunopeptidomics approches. The neoantige...
EGAS00001006633 | EGA
TranscriptomicsRNF43 p.G659fs Leads to Natural Killer Cell Dysfunction in MSI-high Colorectal Cancer Through PI3K/AKT/mTOR Signaling and HLA-E Upregulation
The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability-high (MSI-H) tumors. While RNF43659mut promotes tumor growth through PI3K/AKT/mTOR activation independent of WNT signaling, its immunologic effects are poorly defined. We...
ORGANISM(S): Homo sapiens 
2026-09-21 | GSE342684 | GEO
UnknownNovel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids.
Not available
S-EPMC8448508 | biostudies-literature
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