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TranscriptomicsMsi2 sustains the MLL leukemia stem cell regulatory program
Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Genetic and epigenetic alterations cause a dysregulated developmental program in leukemia. The MSI2 RNA binding protein has been previously shown to predict poor survival in leukemia. W...
ORGANISM(S): Mus musculus 
2015-01-15 | E-GEOD-64545 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-22773 | biostudies-arrayexpress
TranscriptomicsTransformation of the intestinal epithelium by the MSI2 RNA binding protein
The MSI2 RNA binding protein has recently emerged as a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Here we demonstrate that MSI2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinom...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64388 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration
The Musashi-2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhancing cell proliferation in hematopoietic and gastrointestinal tissues. However, it is unclear how Msi2 recognizes and regulates mRNA targets in vivo and whether Msi2 primarily controls cell gro...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-71333 | biostudies-arrayexpress
TranscriptomicsGene expression from normal and Msi2 KO mouse LSK cells
Hematopoietic stem and progenitor cells (Lineagelo ScaI+ c-Kit+) were sorted 4 weeks post pIpC injection. RNA was extracted using TRIZOL and RNEASY RNA extraction kit. RNA was then amplified using NUGEN Pico amplification kit, fragmented and hybridized on Mouse Expression Array 430 2.0. Signal norma...
ORGANISM(S): Mus musculus 
2014-01-05 | E-GEOD-53385 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis
This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelera...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22778 | biostudies-arrayexpress
ProteomicsMouse retina from Msi1/Msi2 double knockout in photoreceptor cells
This quantitative protepomics study (TMT10 isobaric labeling) of the protein expression in the retina of Msi1/Msi2 double knockout mouse compared to floxed controls. The Msi1 and Msi2 genes were knocked out in photoreceptor cells using tamoxifen inducible Cre (Cre-ERT2) under the control of Pde6g pr...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-10 | PXD030748 | Pride
Knockout Photorecptor Mouse Msi2 Msi1 Retina 
TranscriptomicsIntestinal epithelial gene expression - TRE-MSI2
Comparison of gene expression in intestinal epithelial cells in the presence or absence of ectopic induction of MSI2 in vivo Total RNA was isolated from preparations of total intestinal epithelial cells taken from the jejunum from 3 control (R26-M2rtTA +doxycycline for 24 hrs) and 3 experimental (TR...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-64643 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22775 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-22774 | biostudies-arrayexpress
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