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TranscriptomicsPOLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA
Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by both the nuclear and mitochondrial genomes (mtDNA). Transcription of the circular mammalian mtDNA depends on a single mitochondrial RNA polyme...
ORGANISM(S): Mus musculus 
2016-08-05 | E-GEOD-83368 | biostudies-arrayexpress
GenomicsMammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication
PRJNA818872 | ENA
ProteomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-19 | PXD021799 | Pride
Mtdna Tmt Replication Mtssb 
GenomicsMammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication
PRJNA821469 | ENA
GenomicsDNA-seq of mitochondrial DNA from liver of OGG1 and MUTYH deficient mice that have been bred for five consecutive generations
Studying whether removal of base-excision repair from mitochondria will result into increase in mitochondrial DNA (mtDNA) mutation load. The endogenous genes of OGG1 and MUTYH DNA glycosylases were modified to lack the genomic region encoding for the predicted mitochondrial targeting sequence. The m...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6532 | biostudies-arrayexpress
GenomicsDNA-seq of mitochondrial DNA from mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mitochondrial DNA mutation load. Oxidative stress has been suggested to induce mutations in mtDNA. To verify this, we extracted and sequenced (Illu...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6533 | biostudies-arrayexpress
GenomicsMammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication [RNA-seq]
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication [RNA-seq]
PRJNA818639 | ENA
GenomicsMammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication [small RNA-seq]
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for precise termination of mtDNA replication [small RNA-seq]
PRJNA818649 | ENA
GenomicsMyc regulation of ETC Biogenesis and mtDNA Replication
Myc regulation of ETC Biogenesis and mtDNA Replication
PRJNA524122 | ENA
ProteomicsMice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009138 | Pride
Mtdna deletions Mgme1 knock out Progeria 
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