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TranscriptomicsSingle-cell transcriptome sequencing from mouse mTECs
Promiscuous gene expression (pGE) of tissue-restricted antigens in medullary thyme ephitelial cells (mTECs) is essential for self-tolerance induction and to prevent autoimmunity. We sequenced single mTEC transcriptomes to explore gene expression heterogeneity and to discover patterns of regulation o...
ORGANISM(S): Mus musculus 
2015-08-02 | E-MTAB-3346 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome sequencing from mouse mTECs (additional data)
Promiscuous gene expression (pGE) of tissue-restricted antigens in medullary thyme ephitelial cells (mTECs) is essential for self-tolerance induction and to prevent autoimmunity. We sequenced single mTEC transcriptomes to explore gene expression heterogeneity and to discover patterns of regulation o...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-MTAB-3624 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs)
Analysis of the role of Hipk2 in regulating gene expression in medullary thymic epithelial cells. The whole genome gene signatures of purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63432 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Fezf2 in mTECs
ChIP-seq analysis of Fezf2 in mTECs
PRJNA605199 | ENA
GenomicsIdentification of a novel Aire-regulating cis-regulatory element using H3K27ac ChIP-seq
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-74257 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in mTECs
Genome-wide maps of chromatin state in mTECs
PRJNA433526 | ENA
TranscriptomicsmRNA expression profile of medullary thymic epithelial cells-mTECs- of BALBc mice
The medullary thymic epithelial cells (mTECs) express virtually all autoantigens of the body. This phenomenon was then termed promiscuous gene expression (PGE). A large set of autoantigen genes (but not all) is controlled by the transcriptional modulator Autoimmune regulator (Aire) in mTECs. These ...
ORGANISM(S): Mus musculus 
2014-04-18 | E-MEXP-3881 | biostudies-arrayexpress
UnknownThe single-cell transcriptome of mTECs and CD4+ thymocytes under adhesion revealed heterogeneity of mTECs and a network controlled by Aire and lncRNAs.
Not available
S-EPMC11425717 | biostudies-literature
GenomicsSingle-cell transcriptome sequencing from mouse mTECs
Single-cell transcriptome sequencing from mouse mTECs
PRJEB8614 | ENA
GenomicsJmjd3 is required for tissue-restricted antigens expression in mTECs
Jmjd3 is required for tissue-restricted antigens expression in mTECs
PRJNA433532 | ENA
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